TNFSF18 Antibody (OAPB00337)

Catalog No: OAPB00337

Size:100UG

Click here to learn more about Aviva's By-Request Conjugation Service.

Western blot analysis of (A) 5 ng, (B) 25 ng, and (C) 50 ng of purified recombinant GITRL with ITRL antibody at 1 μg/mL.

Immunocytochemistry of GITRL in THP-1 cells with GITRL antibody at 10 μg/mL.

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid. GITRL Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunocytochemistry|Western blot
  Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
• Reconstitution and Storage: GITRL antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: GITRL antibody was raised against purified recombinant human GITR ligand.
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Human; Mouse
• Concentration: 1 mg/ml
• Application Info: GITRL antibody can be used for the detection of GITRL by Western blot at 1 ug/ml. (Optimal dilution should be determined by user)
• Reference: Gaur U, Aggarwal BB. Regulation of proliferation, survival and apoptosis by members of the TNF superfamily. Biochem. Pharmacol. 2003; 66:1403-8.;Ronchetti S, Nocentini G, Riccardi C, et al. Role of GITR in activation response of T lymphocytes.Blood 2002; 100:350-2.;Shimizu J, Yamakai S, Takahashi T, et al. Stimulation of CD25(+) CD4(+) regulatory T cells through GITR breaks immunological self- tolerance. Nat. Immunol. 2002;3:135-42.;Gurney AL, Marsters SA, Huang A, et al. Identification of a new member of the tumor necrosis factor family and its receptor, a human ortholog of mouse GITR. Curr. Biol. 1999; 9:215-218.

Target Info

• Gene Symbol: TNFSF18
• Gene Full Name: TNF superfamily member 18
• Alias Symbols: activation-inducible TNF-related ligand;AITR ligand;AITRL;GITR ligand;GITRL;glucocorticoid-induced TNF-related ligand;glucocorticoid-induced TNFR-related protein ligand;hGITRL;TL6;TNLG2A;tumor necrosis factor (ligand) superfamily, member 18;tumor necrosis factor ligand 2A;tumor necrosis factor ligand superfamily member 18;tumor necrosis factor superfamily member 18.
• NCBI Gene Id: 8995
• Protein Name: Tumor necrosis factor ligand superfamily member 18
• Description of Target: Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation (By similarity).
• Uniprot ID: Q9UNG2
• Protein Accession #: NP_005083.2
• Nucleotide Accession #: NM_005092.3