TNFSF10 Antibody - N-terminal region : Biotin (AVARP02040_P050-Biotin)

Catalog No: AVARP02040_P050-Biotin

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Dog, Pig
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Biotin
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TNFSF10
• Predicted Homology Based on Immunogen Sequence: Dog: 80%; Human: 100%; Pig: 78%
• Peptide Sequence: Synthetic peptide located within the following region: CFLKEDDSYWDPNDEESMNSPCWQVKWQLRQLVRKMILRTSEETISTVQE
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-TNFSF10 (AVARP02040_P050-Biotin) antibody is Catalog # AAP30629 (Previous Catalog # AAPP01282)
• Reference: Wu,Y.Y., et al., (2004) World J. Gastroenterol. 10 (16), 2334-2339
• Publications:

  Ceballos, M. P. et al. FoxO3a Nuclear Localization and Its Association with β-Catenin and Smads in IFN--alpha-Treated Hepatocellular Carcinoma Cell Lines. J. Interferon Cytokine Res. (2014). doi:10.1089/jir.2013.0124 WB, Dog, Human, Pig 24950290

Target Info

• Gene Symbol: TNFSF10
• Gene Full Name: Tumor necrosis factor (ligand) superfamily, member 10
• Alias Symbols: TL2, APO2L, CD253, TRAIL, Apo-2L, TNLG6A
• NCBI Gene Id: 8743
• Protein Name: Tumor necrosis factor ligand superfamily member 10
• Description of Target: TNFSF10 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3.
• Uniprot ID: P50591
• Protein Accession #: NP_003801
• Nucleotide Accession #: NM_003810
• Protein Size (# AA): 281
• Molecular Weight: 33kDa
• Protein Interactions: CASP8; CASP3; CFLAR; TNFRSF10B; FADD; RIPK1; TRAF2; TNFAIP3; SOCS3; RBM48; TNFRSF10D; TNFRSF10C; TNFRSF10A; TNFSF10; TNFRSF11B; ACP5; IER3; CREBBP; SP3; SP1; HDAC5; HDAC4; HDAC3; HDAC2; HDAC1; HIST3H3;