TNFRSF1A Antibody (OAED00061)

Catalog No: OAED00061

Size:50 ug

Western blot analysis of TNF-R1: Lane 1: MW marker; Lane 2: Hela (HS); Lane 3: Jurkat

Immunohistochemistry analysis of human spleen tissue stained with TNF receptor 1 pAb at 10 ug/ml.

Product Info

• Predicted Species Reactivity: Bovine|Dog|Drosophila|Hamster|Human|Monkey|Mouse|Porcine|Rabbit|Rat|Sheep|Xenopus|Yeast
• Clonality: Polyclonal
• Host: Rabbit
• Application: Immunoprecipitation|Western blot
• Reconstitution and Storage: Long Term Storage : -20C
  
• Immunogen: Synthetic peptide corresponding to a portion of mouse TNF-R1. The sequence is completely conserved in rat and human.
• Specificity: Recognizes human, mouse, rat, bovine, dog, Drosophila, hamster, monkey, pig, rabbit, sheep, Xenopus and yeast TNF-R1. Detects a band of 55kDa by Western blot.
• Formulation: Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.
• Purity: Peptide affinity purified.
  
• Application Info: Immunohistochemistry (paraffin sections)
  Immunoprecipitation (12.5μg/ml)
  Western Blot (1:1000, ECL)
  Optimal conditions must be determined individually for each application.
• Reference: Chronic physiological shear stress inhibits tumor necrosis factor-induced proinflammatory responses in rabbit aorta perfused ex vivo: H. Yamawaki, et al.; Circulation 108, 1619 (2003), Application(s): IP, WB using rabbit samples, Abstract;
  TNF-R1 signaling: a beautiful pathway: G. Chen & D.V. Goeddel; Science 296, 1634 (2002), Abstract;
  Induction of Jak/STAT signaling by activation of the type 1 TNF receptor: D. Guo, et al.; J. Immunol. 160, 2742 (1998), Abstract;
  Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38: T. Yuasa, et al.; J. Biol. Chem. 273, 22681 (1998), Abstract;
  A novel domain within the 55 kd TNF receptor signals cell death: L.A. Tartaglia, et al.; Cell 74, 845 (1993), Abstract;
  Two human TNF receptors have similar extracellular, but distinct intracellular, domain sequences: Z. Dembic, et al.; Cytokine 2, 231 (1990), Abstract;

Target Info

• Gene Symbol: Tnfrsf1a
• Gene Full Name: tumor necrosis factor receptor superfamily, member 1a
• Alias Symbols: CD120;CD120a;FPF;p5;p55;p55-R;p60;TN;Tnf;TNF-;TNF receptor alpha chain;TNF-a;TNFal;TNFalpha-R1;TNF-alphaR1;TNF-alpha-R1;TNFAR;TNFR;TNF-R;Tnfr1;TNF-R1;Tnfr-2;TNF-R55;TNFR60;TNFRI;TNFR-I;TNF-RI;TNF-R-I;TNFRp55;tumor necrosis factor receptor 1;tumor necrosis factor receptor superfamily member 1A;tumor necrosis factor receptor type I.
• NCBI Gene Id: 21937
• Protein Name: Tumor necrosis factor receptor superfamily member 1A
• Description of Target: Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis (By similarity).
• Uniprot ID: P25118
• Protein Accession #: NP_001056.1
• Nucleotide Accession #: NM_001065.3