TNFRSF1A Antibody - N-terminal region (AVARP00034_P050)

Catalog No: AVARP00034_P050

Host: Rabbit
Target Name: TNFRSF1A
Sample Tissue: Human Jurkat Whole Cell
Antibody Dilution: 1ug/ml

Host: Rabbit
Target Name: TNFRSF1A
Sample Tissue: Human A549 Whole Cell
Antibody Dilution: 1ug/ml

Immunofluorescent TNFRSF1A detection in human lymphocytes (green fluorescence). Nuclei were stained with DAPI (blue fluorescence).
Working dilution 5-10 ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Guinea Pig
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: IF, WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TNFRSF1A
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Guinea Pig: 84%; Human: 100%; Mouse: 92%
• Peptide Sequence: Synthetic peptide located within the following region: MGLSTVPDLLLPLVLLELLVGIYPSGVIGLVPHLGDREKRDSVCPQGKYI
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-TNFRSF1A (AVARP00034_P050) antibody is Catalog # AAP30521 (Previous Catalog # AAPP01157)
• Sample Type Confirmation:

  TNFRSF1A is supported by BioGPS gene expression data to be expressed in DU145

• Enhanced Validation:

  WB	Y
  SPR
  YCHAROS

Target Info

• Reference: Gattorno,M., (2008) Arthritis Rheum. 58 (6), 1823-1832
• Gene Symbol: TNFRSF1A
• Gene Full Name: Tumor necrosis factor receptor superfamily, member 1A
• Alias Symbols: FPF, p55, p60, TBP1, TNF-R, TNFAR, TNFR1, p55-R, CD120a, TNFR55, TNFR60, TNF-R-I, TNF-R55
• NCBI Gene Id: 7132
• Protein Name: Tumor necrosis factor receptor superfamily member 1A
• Description of Target: TNFRSF1A is the receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. TNFRSF1A contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase.The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Uniprot ID: P19438
• Protein Accession #: NP_001056
• Nucleotide Accession #: NM_001065
• Protein Size (# AA): 455
• Molecular Weight: 50 kDa
• Protein Interactions: RIPK1; UBC; UCHL1; TNF; STAMBP; RNF8; TRAF2; TRADD; ADAM17; LTA; SRC; SHARPIN; KHDRBS1; IKBKB; CHUK; MAP3K7; PPP1CA; PIK3R1; JAK2; ATF6; PRDX3; OPTN; FADD; TNFRSF1A; SGTA; PRKCD; PRKCB; HRG; GYS2; BIRC2; UBQLN1; MAGEH1; SOS1; MYOC; GRB2; DAXX; BIRC3; Traf