TNFRSF12A Antibody (OAEE00170)

Catalog No: OAEE00170

Size:100UG

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Phosphate buffered saline (PBS), pH 7.4
• Clonality: Monoclonal
• Clone: ITEM-4
• Isotype: IgG2b
• Host: Mouse
• Application: Flow cytometry|Functional assay|Immunohistochemistry-Frozen|Western blot
• Reconstitution and Storage: 2°C to 8°C
• Immunogen: human CD266-transfected P815 cells
• Purification: Purified
• Concentration: 1 mg/ml
• Specificity: The mouse monoclonal antibody ITEM-4 recognizes CD266 / TWEAK R, a TNFR superfamily receptor for CD255 / TWEAK, a TNF-like weak inducer of apoptosis.
• Formulation: Low endotoxin
• Purity: > 95% (by SDS-PAGE)
• Storage Buffer: Azide free phosphate buffered saline (PBS), approx. pH 7.4; 0.2 um filter sterilized. Endotoxin level is less than 0.01 EU/ug of the protein, as determined by the LAL test.
• Reference: Roos C, Wicovsky A, Müller N, Salzmann S, Rosenthal T, Kalthoff H, Trauzold A, Seher A, Henkler F, Kneitz C, Wajant H: Soluble and transmembrane TNF-like weak inducer of apoptosis differentially activate the classical and noncanonical NF-kappa B pathway. J Immunol. 2010 Aug 1;185(3):1593-605.
  Nakayama M, Ishidoh K, Kojima Y, Harada N, Kominami E, Okumura K, Yagita H: Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death. J Immunol. 2003 Jan 1;170(1):341-8.
  Sanz AB, Sanchez-Niño MD, Carrasco S, Manzarbeitia F, Ruiz-Andres O, Selgas R, Ruiz-Ortega M, Gonzalez-Enguita C, Egido J, Ortiz A: Inflammatory cytokines and survival factors from serum modulate tweak-induced apoptosis in PC-3 prostate cancer cells. PLoS One. 2012;7(10):e47440.
  Yoriki R, Akashi S, Sho M, Nomi T, Yamato I, Hotta K, Takayama T, Matsumoto S, Wakatsuki K, Migita K, Yagita H, Nakajima Y: Therapeutic potential of the TWEAK/Fn14 pathway in intractable gastrointestinal cancer. Exp Ther Med. 2011 Jan;2(1):103-108
  

Target Info

• Gene Symbol: TNFRSF12A
• Gene Full Name: TNF receptor superfamily member 12A
• Alias Symbols: CD266;FGF-inducible 14;fibroblast growth factor-inducible immediate-early response protein 14;FN14;tumor necrosis factor receptor superfamily member 12A;TWEAKR;tweak-receptor;type I transmembrane protein Fn14.
• NCBI Gene Id: 51330
• Protein Name: Tumor necrosis factor receptor superfamily member 12A
• Description of Target: Receptor for TNFSF12/TWEAK. Weak inducer of apoptosis in some cell types. Promotes angiogenesis and the proliferation of endothelial cells. May modulate cellular adhesion to matrix proteins.
• Uniprot ID: Q9NP84
• Protein Accession #: NP_057723.1
• Nucleotide Accession #: NM_016639.2