TNFRSF10C Antibody (OAEE00761)

Catalog No: OAEE00761

Size:100UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
• Clonality: Monoclonal
• Clone: TRAIL-R3-02
• Isotype: IgG1
• Host: Mouse
• Conjugation: R-PE
• Application: Flow cytometry
• Reconstitution and Storage: 2°C to 8°C
• Immunogen: TRAIL-R3-hIgGhc fusion protein
• Purification: Purified by size-exclusion chromatography
• Concentration: 0.1 mg/ml
• Specificity: The antibody TRAIL-R3-02 reacts with TRAIL-R3, a 35 kDa GPI-anchored extracellular membrane protein expressed mainly on neutrophils.
• Formulation: PE
• Storage Buffer: The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent.
• Reference: Deligezer U, Dalay N: Expression of the TRAIL Receptors in Blood Mononuclear Cells in Leukemia. Pathol Oncol Res. 2007;13(4):290-4.
  Falschlehner C, Emmerich CH, Gerlach B, Walczak H: TRAIL signalling: decisions between life and death. Int J Biochem Cell Biol. 2007;39(7-8):1462-75.
  Mérino D, Lalaoui N, Morizot A, Schneider P, Solary E, Micheau O: Differential inhibition of TRAIL-mediated DR5-DISC formation by decoy receptors 1 and 2. Mol Cell Biol. 2006 Oct;26(19):7046-55.
  Sanlioglu AD, Dirice E, Aydin C, Erin N, Koksoy S, Sanlioglu S. Surface TRAIL decoy receptor-4 expression is correlated with TRAIL resistance in MCF7 breast cancer cells. BMC Cancer. 2005 May 25;5(1):54.
  Clancy L, Mruk K, Archer K, Woelfel M, Mongkolsapaya J, Screaton G, Lenardo MJ, Chan FK: Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18099-104.

Target Info

• Gene Symbol: TNFRSF10C
• Gene Full Name: TNF receptor superfamily member 10c
• Alias Symbols: antagonist decoy receptor for TRAIL/Apo-2L;CD263;cytotoxic TRAIL receptor-3;DCR1;DCR1-TNFR;decoy receptor 1;decoy TRAIL receptor without death domain;LIT;lymphocyte inhibitor of TRAIL;TNF-related apoptosis-inducing ligand receptor 3;TRAIL receptor without an intracellular domain;TRAILR3;TRAIL-R3;TRID;tumor necrosis factor receptor superfamily member 10C;tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain.
• NCBI Gene Id: 8794
• Protein Name: Tumor necrosis factor receptor superfamily member 10C
• Description of Target: Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
• Uniprot ID: O14798
• Protein Accession #: NP_003832.2
• Nucleotide Accession #: NM_003841.3