Catalog No: OPCD07555
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OPCD07555
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Datasheets/ManualsPrintable datasheet for TNFRSF10B Recombinant Protein (OPCD07555)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Ser234-Ala435
::Subcellular Location: Membrane; Single-pass type I membrane prote
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His and GST Tag
Gene SymbolTNFRSF10B
Gene Full NameTNF receptor superfamily member 10b
Alias Symbolsapoptosis inducing protein TRICK2A/2B;apoptosis inducing receptor TRAIL-R2;CD262;cytotoxic TRAIL receptor-2;death domain containing receptor for TRAIL/Apo-2L;death receptor 5;DR5;Fas-like protein;KILLER;KILLER/DR5;p53-regulated DNA damage-inducible cell death receptor(killer);TNF-related apoptosis-inducing ligand receptor 2;TRAILR2;TRAIL-R2;TRICK2;TRICK2A;TRICK2B;TRICKB;tumor necrosis factor receptor superfamily member 10B;tumor necrosis factor receptor superfamily, member 10b;tumor necrosis factor receptor-like protein ZTNFR9;ZTNFR9.
NCBI Gene Id8795
Protein NameTumor necrosis factor receptor superfamily member 10B
Description of TargetReceptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
Uniprot IDO14763
Protein Accession #NP_003833.4
Nucleotide Accession #NM_003842.4
Protein Size (# AA)Ser234~Ala435
Molecular Weight53kDa
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