TNFRSF10B Recombinant Protein (Human) (OPED00145)

Catalog No: OPED00145

Size:50UG

Fig 1: SDS-PAGE Analysis. Lane 1: MW Marker, Lane 2: 1 ug, Lane 3: 2 ug TRAIL-R2.

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Lyophilized. Contains PBS.
• Host: HEK 293 cells
• Application: ELISA
• Additional Information: Historical data has shown inhibition of human soluble TRAIL-induced apoptosis in a concentration range of 0.5-10ug/ml.
• Reconstitution and Storage: Reconstitute with 50 ul sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein. Store at -20C
• Purity: >95% (SDS-PAGE)
• Application Info: ELISA: binds to TRAIL at 10-100 ng/ml.
• Reference: Serine 574 phosphorylation alters transcriptional programming of FOXO3 by selectively enhancing apoptotic gene expression: Z. Li, et al.; Cell Death Differ. 23, 583 (2016), Abstract;
  Death receptor 5 signaling promotes hepatocyte lipoapoptosis: S.C. Cazanave, et al.; J. Biol. Chem. 286, 39336 (2011), Abstract;
  Proteasome inhibition can induce an autophagy-dependent apical activation of caspase-8: M.A. Laussmann, et al.; Cell Death Differ. 18, 1584 (2011), Abstract;
  Two adjacent trimeric fas ligands are required for fas signaling and formation of a death-inducing signaling complex: N. Holler, et al.; Mol. Cell. Biol. 23, 1428 (2003), Abstract; Full Text
  Death ligand TRAIL induces no apoptosis but inhibits activation of human (auto)antigen-specific T cells: J.D. Lunemann, et al.; J. Immunol. 168, 4881 (2002), Abstract; Full Text
  Induction of TRAIL-mediated glioma cell death by human T cells: J. Dörr, et al.; J. Neuroimmunol. 122, 117 (2002), Abstract;
  Innate direct anticancer effector function of human immature dendritic cells. II. Role of TNF, lymphotoxin-alpha (1)beta (2), Fas ligand, and TNF-related apoptosis-inducing ligand: G. Lu, et al.; J. Immunol. 168, 1831 (2002), Abstract; Full Text
  Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling in Activated T Cells Abrogates TRAIL-Induced Apoptosis Upstream of the Mitochondrial Amplification Loop and Caspase-8: T.S. Soderstrom, et al.; J. Immunol. 169, 2851 (2002), Abstract;
  T cells require TRAIL for optimal graft-versus-tumor activity: C. Schmaltz, et al.; Nat. Med. 8, 1433 (2002), Abstract;
  TRAIL/Apo-2 ligand induces primary plasma cell apoptosis: J. Ursini-Siegel, et al.; J. Immunol. 169, 5505 (2002), Abstract; Full Text
  Development of improved soluble inhibitors of FasL and CD40L based on oligomerized receptors: N. Holler, et al.; J. Immunol. Methods 237, 159 (2000), Abstract;
  The tumor necrosis factor-related apoptosis-inducing ligand receptors TRAIL-R1 and TRAIL-R2 have distinct cross-linking requirements for initiation of apoptosis and are non-redundant in JNK activation: F. Mühlenbeck, et al.; J. Biol. Chem. 275, 32208 (2000), Abstract; Full Text

Target Info

• Gene Symbol: TNFRSF10B
• Gene Full Name: TNF receptor superfamily member 10b
• Alias Symbols: apoptosis inducing protein TRICK2A/2B;apoptosis inducing receptor TRAIL-R2;CD262;cytotoxic TRAIL receptor-2;death domain containing receptor for TRAIL/Apo-2L;death receptor 5;DR5;Fas-like protein;KILLER;KILLER/DR5;p53-regulated DNA damage-inducible cell death receptor(killer);TNF-related apoptosis-inducing ligand receptor 2;TRAILR2;TRAIL-R2;TRICK2;TRICK2A;TRICK2B;TRICKB;tumor necrosis factor receptor superfamily member 10B;tumor necrosis factor receptor superfamily, member 10b;tumor necrosis factor receptor-like protein ZTNFR9;ZTNFR9.
• NCBI Gene Id: 8795
• Protein Name: Tumor necrosis factor receptor superfamily member 10B
• Description of Target: Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.
• Uniprot ID: O14763
• Protein Size (# AA): Recombinant
• Molecular Weight: 58 kDa