TNFRSF10B Antibody (OAAB21142)

Catalog No: OAAB21142

Size:100ul

Western blot detection of DR5 in Mouse kindey, Mouse brain, HCT116 and Hela cell lysates using DR5 mouse mAb (OAAB21142) (1:500-1:2,000 diluted). Predicted band size: 40/48KDa. Observed band size: 40/48KDa.

Immunocytochemistry of Hela cells fixed by Paraformaldehyde and using DR5 mouse mAb (OAAB21142) diluted 1:100.

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid
• Clonality: Monoclonal
• Host: Rabbit
• Application: WB, ICC
• Additional Information: Function: Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B. Essential for ER stress-induced apoptosis.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Predicted Homology Based on Immunogen Sequence: Human, Mouse
• Preservative: 0.02% Sodium Azide, 0.1% BSA, and 50% glycerol
• Formulation: Purified mouse monoclonal in PBS (pH 7.4) containing with 0.02% sodium azide,0.1% BSA and 50% glycerol.
• Application Info: WB: 1:500~1:2000
  ICC: 1:100
• Reference: Screaton G.R.,et al.Curr. Biol. 7:693-696(1997).
  Walczak H.,et al.EMBO J. 16:5386-5397(1997).
  Schneider P.,et al.FEBS Lett. 416:329-334(1997).
  Chaudhary P.M.,et al.Immunity 7:821-830(1997).
  MacFarlane M.,et al.J. Biol. Chem. 272:25417-25420(1997).
  

Target Info

• Gene Symbol: TNFRSF10B
• Gene Full Name: tumor necrosis factor receptor superfamily member 10b
• Alias Symbols: DR5, CD262, KILLER, TRICK2, TRICKB, ZTNFR9, TRAILR2, TRICK2A, TRICK2B, TRAIL-R2, KILLER/DR5
• NCBI Gene Id: 8795
• Description of Target: The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene.
• Uniprot ID: O14763
• Protein Accession #: NP_003833.4
• Nucleotide Accession #: NM_003842.4
• Molecular Weight: 48 kDa