Catalog No: OAPB00022 (Formerly GWB-A9753D)
Size:100UG
Price: $461.00
SKU
OAPB00022
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
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Datasheets/ManualsPrintable datasheet for TNFRSF10A Antibody (OAPB00022) (OAPB00022)
Product Info
Predicted Species ReactivityHuman|Mouse|Rat
Product FormatLiquid. DR4 Antibody is supplied in PBS containing 0.02% sodium azide.
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
ApplicationEnzyme-linked immunosorbent assay|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
Additional InformationHeLa Cell Lysate (OCPB00181)
::Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
Reconstitution and Storage2°C to 8°C
ImmunogenAnti-DR4 antibody (1139) was raised against a peptide corresponding to 19 amino acids near the carboxy terminus of human DR4. The immunogen is located within the last 50 amino acids of DR4.
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceHuman
Concentration1 mg/ml
Blocking PeptideFor anti-TNFRSF10A (OAPB00022) antibody is Catalog # OEPB02151
Application InfoDR4 antibody can be used for detection of DR4 expression by Western blot at 1:500 to 1:1000 dilution. A 57 kDa band should be detected. (Optimal dilution should be determined by user)
ReferencePan G; O'Rourke K; Chinnaiyan AM; O'Rourke K; Gentz R; Ebner R; Ni J; Dixit VM. The receptor for the cytotoxic ligand TRAIL. Science; 1997;276:111-113 ;Wiley SR, Schooley K, Smolak PJ, Din WS, Huang CP, Nicholl JK, Sutherland GR, Smith TD, Rauch C, Smith CA, et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 1995;3:673-682 ;Pitti RM; Marsters SA; Ruppert S; Donahue CJ; Moore A; Ashkenazi A. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 1996;271:12687-90;Schneider P, Thome M, Burns K, Bodmer JL, Hofmann K, Kataoka T, Holler N, Tschopp J. TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB. Immunity 1997;7:831-836 (RD1299)
Gene SymbolTNFRSF10A
Gene Full NameTNF receptor superfamily member 10a
Alias SymbolsAPO2;CD261;cytotoxic TRAIL receptor;death receptor 4;DR4;TNF-related apoptosis-inducing ligand receptor 1;TRAIL receptor 1;TRAILR1;TRAILR-1;TRAIL-R1;tumor necrosis factor receptor superfamily member 10A;tumor necrosis factor receptor superfamily member 10a variant 2;tumor necrosis factor receptor superfamily, member 10a.
NCBI Gene Id8797
Protein Namecytotoxic ligand TRAIL receptor [Homo sapiens]|Tumor necrosis factor receptor superfamily member 10A
Description of TargetReceptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.
Uniprot IDO00220
Protein Accession #https://www.ncbi.nlm.nih.gov/protein/AAC51226
Nucleotide Accession #NM_003844.3
Molecular WeightPredicted: 50kD Observed: 55kD (Post-modification: 1 N-linked glycosylation)
  1. What is the species homology for "TNFRSF10A Antibody (OAPB00022)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human|Mouse|Rat".

  2. How long will it take to receive "TNFRSF10A Antibody (OAPB00022)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "TNFRSF10A Antibody (OAPB00022)" provided in?

    This item is provided in "Liquid. DR4 Antibody is supplied in PBS containing 0.02% sodium azide.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "TNFRSF10A Antibody (OAPB00022)"?

    This target may also be called "APO2;CD261;cytotoxic TRAIL receptor;death receptor 4;DR4;TNF-related apoptosis-inducing ligand receptor 1;TRAIL receptor 1;TRAILR1;TRAILR-1;TRAIL-R1;tumor necrosis factor receptor superfamily member 10A;tumor necrosis factor receptor superfamily member 10a variant 2;tumor necrosis factor receptor superfamily, member 10a." in publications.

  5. What is the shipping cost for "TNFRSF10A Antibody (OAPB00022)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "TNFRSF10A Antibody (OAPB00022)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "TNFRSF10A Antibody (OAPB00022)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "Predicted: 50kD Observed: 55kD (Post-modification: 1 N-linked glycosylation)".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "TNFRSF10A Antibody (OAPB00022)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "TNFRSF10A"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "TNFRSF10A"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "TNFRSF10A"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "TNFRSF10A"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "TNFRSF10A"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "TNFRSF10A"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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