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Datasheets/Manuals | Printable datasheet for TNFRSF10A Antibody (OAEE00756) (OAEE00756) |
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Predicted Species Reactivity | Human |
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Product Format | Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide |
Clonality | Monoclonal |
Clone | DR-4-02 |
Isotype | IgG1 |
Host | Mouse |
Conjugation | FITC |
Application | Flow cytometry |
Reconstitution and Storage | 2°C to 8°C |
Immunogen | Fusion protein containing the extracellular part of TRAIL-R1 and the constant part of the heavy chain of the human IgG1. |
Purification | Purified by size-exclusion chromatography |
Concentration | 0.1 mg/ml |
Specificity | The antibody DR-4-02 recognizes TRAIL-R1 (DR4), a human death receptor 4 (468 amino acids) expressed in most human tissues (spleen, peripheral blood leucocytes, thymus) and in a variety of tumour-derived cell lines. |
Formulation | FITC |
Storage Buffer | The reagent is provided in phosphate buffered saline (PBS) containing 15 mM sodium azide and 0.2% (w/v) high-grade protease free Bovine Serum Albumin (BSA) as a stabilizing agent. |
Reference | Simova S, Klima M, Cermak L, Sourkova V, Andera L: Arf and Rho GAP adapter protein ARAP1 participates in the mobilization of TRAIL-R1/DR4 to the plasma membrane. Apoptosis. 2008 Mar;13(3):423-36. Corallini F, Milani D, Nicolin V, Secchiero P: TRAIL, caspases and maturation of normal and leukemic myeloid precursors. Leuk Lymphoma. 2006 Aug;47(8):1459-68. |
Gene Symbol | TNFRSF10A |
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Gene Full Name | TNF receptor superfamily member 10a |
Alias Symbols | APO2;CD261;cytotoxic TRAIL receptor;death receptor 4;DR4;TNF-related apoptosis-inducing ligand receptor 1;TRAIL receptor 1;TRAILR1;TRAILR-1;TRAIL-R1;tumor necrosis factor receptor superfamily member 10A;tumor necrosis factor receptor superfamily member 10a variant 2;tumor necrosis factor receptor superfamily, member 10a. |
NCBI Gene Id | 8797 |
Protein Name | Tumor necrosis factor receptor superfamily member 10A |
Description of Target | Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:26457518). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. |
Uniprot ID | O00220 |
Protein Accession # | NP_003835.3 |
Nucleotide Accession # | NM_003844.3 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "TNFRSF10A Antibody (OAEE00756)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "TNFRSF10A Antibody (OAEE00756)"?
This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".
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What buffer format is "TNFRSF10A Antibody (OAEE00756)" provided in?
This item is provided in "Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "TNFRSF10A Antibody (OAEE00756)"?
This target may also be called "APO2;CD261;cytotoxic TRAIL receptor;death receptor 4;DR4;TNF-related apoptosis-inducing ligand receptor 1;TRAIL receptor 1;TRAILR1;TRAILR-1;TRAIL-R1;tumor necrosis factor receptor superfamily member 10A;tumor necrosis factor receptor superfamily member 10a variant 2;tumor necrosis factor receptor superfamily, member 10a." in publications.
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What is the shipping cost for "TNFRSF10A Antibody (OAEE00756)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "TNFRSF10A Antibody (OAEE00756)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "TNFRSF10A Antibody (OAEE00756)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "TNFRSF10A Antibody (OAEE00756)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "TNFRSF10A"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "TNFRSF10A"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "TNFRSF10A"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "TNFRSF10A"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "TNFRSF10A"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "TNFRSF10A"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.