Catalog No: OPCA01905
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OPCA01905
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TNF Recombinant Protein (Sheep) (OPCA01905)

Datasheets/ManualsPrintable datasheet for TNF Recombinant Protein (Sheep) (OPCA01905) (OPCA01905)
Product Info
Predicted Species ReactivityOvis aries|Sheep
Product FormatLiquid or Lyophilized powder
HostSheep
Additional InformationRelevance: Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
Reconstitution and Storage-20°C or -80°C
Formulation20 mM Tris-HCl based buffer, pH 8.0
PurityGreater than 90% as determined by SDS-PAGE.
Peptide SequenceLRSSSQASNNKPVAHVVANISAPGQLRWGDSYANALMANGVELKDNQLVVPTDGLYLIYSQVLFRGHGCPSTPLFLTHTISRIAVSYQTKVNILSAIKSPCHRETLEGAEAKPWYEPIYQGGVFQLEKGDRLSAEINLPEYLDYAESGQVYFGIIAL
Protein SequenceLRSSSQASNNKPVAHVVANISAPGQLRWGDSYANALMANGVELKDNQLVVPTDGLYLIYSQVLFRGHGCPSTPLFLTHTISRIAVSYQTKVNILSAIKSPCHRETLEGAEAKPWYEPIYQGGVFQLEKGDRLSAEINLPEYLDYAESGQVYFGIIAL
Storage BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
SourceE.coli
Protein Range78-234 aa
TagN-terminal GST-tagged
ReferenceMolecular cloning, expression and characterization of ovine TNF alpha.Andrews A.E., Nash A.D., Barcham G.J., Brandon M.R.Immunol. Cell Biol. 69:273-283(1991)
Gene SymbolTNF
Gene Full Nametumor necrosis factor
Alias Symbolscachectin;TNF-a;TNF-alpha;tumor necrosis factor;tumor necrosis factor (TNF superfamily, member 2);tumor necrosis factor alpha;tumor necrosis factor ligand superfamily member 2.
NCBI Gene Id443540
Protein NameTumor necrosis factor
Description of TargetCytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
Uniprot IDP23383
Protein Accession #NP_001020031.1
Nucleotide Accession #NM_001024860.1
Protein Size (# AA)Recombinant
Molecular Weight44.2 kDa
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