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Catalog No: OAPA00025 (Formerly GWB-782E70)
Size:500UG
Price: $334.00
SKU
OAPA00025
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
  • Contact us for international orders.

TNF-a Antibody (OAPA00025)

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Tumor necrosis factor is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF is mainly secreted by macrophages. TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis and viral replication, TNF is also involved in lipid metabolism, and coagulation. TNF's primary role is in the regulation of immune cells. Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases- autoimmune diseases, insulin resistance, and cancer.
Datasheets/ManualsPrintable datasheet for anti-TNF-a antibody - OAPA00025
Product Info
Predicted Species ReactivityHuman
Product FormatLyophilized PBS
ClonalityMonoclonal
CloneNYRhTNFa-E2.
IsotypeMouse IgG1.
HostMouse
ApplicationELISA, WB, IP, Intracellular staining
Additional InformationNote: This antibody will bind very well to protein A in a buffer (PBS) containing high salt concentration (3M NaCl).
Reconstitution and StorageAntibody is shipped lyophilized at ambient temperature. Reconstitute with sterile H2O. Mix gently, wash the sides of the vial and wait 30-60 seconds before use. In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.
Immunogenr. Human TNF-a.
Concentration1 mg/ml (after reconstitution)
Purityion exchange.
Application InfoIn direct ELISA, using alkaline phosphatase goat anti-mouse Ig 1:10,000 dilution will yield 0.7 O.D. within 10 minutes.
Gene SymbolTNF
Alias SymbolsDIF, TNFA, TNFSF2, TNLG1F, TNF-alpha
NCBI Gene Id7124
Protein NameTumor necrosis factor
Description of TargetMouse Anti Human Tumor Necrosis Factor-alpha
Uniprot IDP01375
Protocol:
Tips Information:

See our General FAQ page.

Protein interactions
Name# of Products
ADAM1758
ADAM977
BGN69
BIRC2191
BTRC289
CAV1348
CDC42228
CHUK193
CSF161
DCN101
FAS111
FBXW11145
HSP90B3P29
HSPB198
HSPB256
IFNG75
IKBKB287
IKBKG419
MAP3K7189
MMP1732
PDIK1L29
POU29
PRTN398
RAC1285
RBCK170
RIPK1179
RNF3143
TAB1148
TAB276
TBK1158
TNF213
TNFAIP3141
TNFRSF1A185
TNFRSF1B70
TNIP145
TRADD157
TRAF2432
UBC7030
UBE2N169
Biological pathways
Name# of Products
Activation of cysteine-type endopeptidase activity involved in apoptotic process193
Activation of MAPK activity317
Activation of MAPKKK activity44
Anti-apoptosis727
Cellular response to nicotine38
Chronic inflammatory response to antigenic stimulus33
Embryonic digestive tract development59
Induction of apoptosis via death domain receptors84
Induction of necroptosis by extracellular signals44
Leukocyte tethering or rolling56
Necrotic cell death45
Negative regulation of branching involved in lung morphogenesis29
Negative regulation of cytokine secretion involved in immune response90
Negative regulation of fat cell differentiation103
Negative regulation of interleukin-6 production98
Negative regulation of lipid catabolic process87
Negative regulation of lipid storage119
Negative regulation of viral genome replication72
Positive regulation of calcidiol 1-monooxygenase activity61
Positive regulation of chemokine biosynthetic process61
Positive regulation of chemokine production128
Positive regulation of cytokine secretion124
Positive regulation of ERK1 and ERK2 cascade194
Positive regulation of fever generation60
Positive regulation of heterotypic cell-cell adhesion35
Positive regulation of I-kappaB kinase/NF-kappaB cascade414
Positive regulation of membrane protein ectodomain proteolysis87
Positive regulation of NFAT protein import into nucleus29
Positive regulation of NF-kappaB import into nucleus114
Positive regulation of NF-kappaB transcription factor activity346
Positive regulation of nitric oxide biosynthetic process220
Positive regulation of osteoclast differentiation112
Positive regulation of peptidyl-serine phosphorylation168
Positive regulation of podosome assembly49
Positive regulation of protein complex disassembly29
Positive regulation of smooth muscle cell proliferation123
Positive regulation of transcription from RNA polymerase II promoter1210
Positive regulation of vitamin D biosynthetic process55
Protein import into nucleus, translocation102
Receptor biosynthetic process57
Regulation of insulin secretion182
Response to glucocorticoid stimulus111
Response to salt stress40
Response to virus401
Sequestering of triglyceride36
Transformed cell apoptosis42
Tumor necrosis factor-mediated signaling pathway59
Biological process
Name# of Products
Activation of cysteine-type endopeptidase activity involved in apoptotic process100
Activation of MAPK activity105
Activation of MAPKKK activity12
Anti-apoptosis239
Apoptotic process586
Calcium-mediated signaling37
Cell activation16
Cellular response to amino acid stimulus46
Cellular response to nicotine9
Cellular response to organic cyclic compound58
Chronic inflammatory response to antigenic stimulus6
Defense response to Gram-positive bacterium45
Embryonic digestive tract development26
Epithelial cell proliferation involved in salivary gland morphogenesis16
Extracellular matrix organization77
Extrinsic apoptotic signaling pathway11
Glucose metabolic process107
Humoral immune response51
Induction of apoptosis226
Induction of apoptosis by extracellular signals104
Induction of apoptosis via death domain receptors21
Induction of necroptosis by extracellular signals8
Inflammatory response339
Leukocyte tethering or rolling15
Lipopolysaccharide-mediated signaling pathway48
MAPK cascade105
Multicellular organismal development896
Necrotic cell death9
Negative regulation of apoptotic process356
Negative regulation of branching involved in lung morphogenesis5
Negative regulation of cell proliferation375
Negative regulation of cytokine secretion involved in immune response13
Negative regulation of fat cell differentiation35
Negative regulation of gene expression70
Negative regulation of glucose import10
Negative regulation of growth of symbiont in host32
Negative regulation of interleukin-6 production29
Negative regulation of L-glutamate transport3
Negative regulation of lipid catabolic process21
Negative regulation of lipid storage8
Negative regulation of transcription from RNA polymerase II promoter574
Negative regulation of transcription, DNA-dependent520
Negative regulation of viral genome replication24
Organ morphogenesis132
Positive regulation of calcidiol 1-monooxygenase activity16
Positive regulation of chemokine (C-X-C motif) ligand 2 production8
Positive regulation of chemokine biosynthetic process27
Positive regulation of chemokine production34
Positive regulation of chronic inflammatory response to antigenic stimulus6
Positive regulation of cytokine production17
Positive regulation of cytokine secretion38
Positive regulation of ERK1 and ERK2 cascade103
Positive regulation of fever generation19
Positive regulation of hair follicle development8
Positive regulation of heterotypic cell-cell adhesion6
Positive regulation of humoral immune response mediated by circulating immunoglobulin13
Positive regulation of I-kappaB kinase/NF-kappaB cascade160
Positive regulation of interferon-gamma production61
Positive regulation of interleukin-6 production63
Positive regulation of interleukin-8 biosynthetic process11
Positive regulation of JNK cascade68
Positive regulation of MAP kinase activity56
Positive regulation of membrane protein ectodomain proteolysis25
Positive regulation of mitosis50
Positive regulation of necrotic cell death5
Positive regulation of neuron apoptosis53
Positive regulation of NFAT protein import into nucleus6
Positive regulation of NF-kappaB import into nucleus30
Positive regulation of NF-kappaB transcription factor activity135
Positive regulation of nitric oxide biosynthetic process53
Positive regulation of osteoclast differentiation39
Positive regulation of peptidyl-serine phosphorylation63
Positive regulation of podosome assembly14
Positive regulation of programmed cell death9
Cellular components
Name# of Products
Cell surface369
External side of plasma membrane261
Extracellular region1573
Extracellular space884
Integral to plasma membrane817
Intracellular1678
Membrane raft140
Phagocytic cup11
Plasma membrane2678
Recycling endosome29
Protein function
Name# of Products
Cytokine activity1104
Identical protein binding1130
Protease binding376
Protein binding12191
Transcription regulatory region DNA binding657
Tumor necrosis factor receptor binding237

  1. What is the species homology for "TNF-a Antibody (OAPA00025)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "TNF-a Antibody (OAPA00025)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "TNF-a Antibody (OAPA00025)" provided in?

    This item is provided in "Lyophilized PBS".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "TNF-a Antibody (OAPA00025)"?

    This target may also be called "DIF, TNFA, TNFSF2, TNLG1F, TNF-alpha" in publications.

  5. What is the shipping cost for "TNF-a Antibody (OAPA00025)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "TNF-a Antibody (OAPA00025)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "TNF-a Antibody (OAPA00025)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "TNF-a Antibody (OAPA00025)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "TNF"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "TNF"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "TNF"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "TNF"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "TNF"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "TNF"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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