Catalog No: ARP53188_P050
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ARP53188_P050
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TMPRSS6 Antibody - N-terminal region (ARP53188_P050)

Datasheets/ManualsPrintable datasheet for anti-TMPRSS6 (ARP53188_P050) antibody
Product Info
ReferenceFinberg,K.E., (2008) Nat. Genet. 40 (5), 569-571
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationIHC, WB
Additional InformationIHC Information: Paraffin embedded liver tissue, tested with an antibody dilution of 5 ug/ml.
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the N terminal region of human TMPRSS6
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 93%; Guinea Pig: 86%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rat: 100%
Peptide SequenceSynthetic peptide located within the following region: LLWYFLGYKAEVMVSQVYSGSLRVLNRHFSQDLTRRESSAFRSETAKAQK
Concentration0.5 mg/ml
Blocking PeptideFor anti-TMPRSS6 (ARP53188_P050) antibody is Catalog # AAP53188 (Previous Catalog # AAPP36325)
Enhanced Validation
Relative Expression (Western Blot) Avivasheild
Gene SymbolTMPRSS6
Gene Full NameTransmembrane protease, serine 6
Alias SymbolsMT2, IRIDA
NCBI Gene Id164656
Protein NameTransmembrane protease serine 6
Description of TargetTMPRSS6 is a serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. TMPRSS6 can also activate urokinase-type plasminogen activator with low efficiency. TMPRSS6 may play a specialized role in matrix remodeling processes in liver. TMPRSS6 is required to sense iron deficiency. Overexpression of TMPRSS6 suppresses activation of the HAMP promoter.The protein encoded by this gene is a type II transmembrane serine proteinase that is found attached to the cell surface. The encoded protein may be involved in matrix remodeling processes in the liver.
Uniprot IDQ8IU80
Protein Accession #NP_705837
Nucleotide Accession #NM_153609
Protein Size (# AA)811
Molecular Weight90 kDa
Protein InteractionsLAMA1; FN1; COL1A1;
  1. What is the species homology for "TMPRSS6 Antibody - N-terminal region (ARP53188_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig".

  2. How long will it take to receive "TMPRSS6 Antibody - N-terminal region (ARP53188_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "TMPRSS6 Antibody - N-terminal region (ARP53188_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "TMPRSS6 Antibody - N-terminal region (ARP53188_P050)"?

    This target may also be called "MT2, IRIDA" in publications.

  5. What is the shipping cost for "TMPRSS6 Antibody - N-terminal region (ARP53188_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "TMPRSS6 Antibody - N-terminal region (ARP53188_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "TMPRSS6 Antibody - N-terminal region (ARP53188_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "90 kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "TMPRSS6 Antibody - N-terminal region (ARP53188_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "TMPRSS6"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "TMPRSS6"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "TMPRSS6"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "TMPRSS6"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "TMPRSS6"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "TMPRSS6"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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