Catalog No: OPCD07521
Price: $0.00
SKU
OPCD07521
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Datasheets/Manuals | Printable datasheet for TMEM173 Recombinant Protein (OPCD07521) |
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Predicted Species Reactivity | Mouse|Mus musculus |
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Product Format | Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose. |
Host | E.coli |
Conjugation | Unconjugated |
Application | Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot |
Additional Information | Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method) |
:: | Residues: Trp160-Leu371 |
Reconstitution and Storage | 2°C to 8°C|-80°C |
Concentration | 200 ug/mL (prior to lyoph) |
Purity | > 97% |
Source | E.coli |
Tag | N-terminal His Tag |
Gene Symbol | Sting1 |
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Gene Full Name | stimulator of interferon response cGAMP interactor 1 |
Alias Symbols | 2610307O08Rik;E;endoplasmic reticulum interferon stimulator;ERIS;mediator of IRF3 activation;Mita;mitochondrial mediator of IRF3 activation;MP;MPYS;St;stimulator of interferon genes protein;stimulator of interferon protein;STING;STING-beta;Tmem173;transmembrane protein 173. |
NCBI Gene Id | 72512 |
Protein Name | Stimulator of interferon genes protein |
Description of Target | Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:26300263). |
Uniprot ID | Q3TBT3 |
Protein Accession # | NP_001276520.1 |
Nucleotide Accession # | NM_001289591.1 |
Protein Size (# AA) | Trp160~Leu371 |
Molecular Weight | 28kDa |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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