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- Email: info@avivasysbio.com
- $55: Antibody & Protein in US
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Datasheets/Manuals | Printable datasheet for TLR2 Antibody (OABF00382) |
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Predicted Species Reactivity | Bovine|Chicken|Dog|Human|Mouse|Porcine|Rat|Sheep |
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Product Format | Liquid. Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. |
Clonality | Polyclonal |
Isotype | IgG |
Host | Rabbit |
Conjugation | Unconjugated |
Application | Flow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot |
Additional Information | Subcellular location: Cytoplasm |
Reconstitution and Storage | -20°C |
Immunogen | KLH conjugated synthetic peptide derived from human TLR2 (cytoplasmic domain) |
Purification | Protein A Purified |
Concentration | 1 ug/ul |
Application Info | WB: 1:100 - 1000 IHC-P: : 1:100 - 500 FC: 1:20 - 100 |
Gene Symbol | TLR2 |
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Gene Full Name | toll like receptor 2 |
Alias Symbols | CD282;TIL4;toll/interleukin-1 receptor-like protein 4;toll-like receptor 2. |
NCBI Gene Id | 7097 |
Protein Name | Toll-like receptor 2 |
Description of Target | Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205). MAPK activation in response to bacterial peptidoglycan also occurs via this receptor (PubMed:16622205). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36); the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression (PubMed:15809303). Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse) (By similarity). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211). Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM (By similarity). |
Uniprot ID | O60603 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "TLR2 Antibody (OABF00382)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Bovine|Chicken|Dog|Human|Mouse|Porcine|Rat|Sheep".
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How long will it take to receive "TLR2 Antibody (OABF00382)"?
This item is available "3 to 5 business days.".
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What buffer format is "TLR2 Antibody (OABF00382)" provided in?
This item is provided in "Liquid. Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "TLR2 Antibody (OABF00382)"?
This target may also be called "CD282;TIL4;toll/interleukin-1 receptor-like protein 4;toll-like receptor 2." in publications.
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What is the shipping cost for "TLR2 Antibody (OABF00382)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "TLR2 Antibody (OABF00382)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "TLR2 Antibody (OABF00382)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "TLR2 Antibody (OABF00382)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "TLR2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "TLR2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "TLR2"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "TLR2"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "TLR2"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "TLR2"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.