TJP2 Antibody (Phospho-Ser978) (OAAB16339)

Catalog No: OAAB16339

Size:400ul

Dot blot analysis of Phospho-TJP2-S978 Antibody Phospho-specific Pab (Cat. # OAAB16339) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.6ug per ml.

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: DB
  Function: Plays a role in tight junctions and adherens junctions.
  Cellular Location: Cell junction, adherens junction. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell junction, tight junction {ECO:0000250|UniProtKB:Q9Z0U1}. Nucleus. Note=Also nuclear under environmental stress conditions and in migratory endothelial cells and subconfluent epithelial cell cultures.
  Tissue Location: This protein is found in epithelial cell junctions. Isoform A1 is abundant in the heart and brain. Detected in brain and skeletal muscle. It is present almost exclusively in normal tissues. Isoform C1 is expressed at high level in the kidney, pancreas, heart and placenta. Not detected in brain and skeletal muscle. Found in normal as well as in most neoplastic tissues.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This TJP2 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S978 of human TJP2.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: DB: 1:500

Target Info

• Gene Symbol: TJP2
• Alias Symbols: ZO2, X104, FHCA1, PFIC4, DFNA51, DUP9q21.11, C9DUPq21.11
• NCBI Gene Id: 9414
• Protein Name: Tight junction protein ZO-2
• Description of Target: This gene encodes a zonula occluden that is a member of the membrane-associated guanylate kinase homolog family. The encoded protein functions as a component of the tight junction barrier in epithelial and endothelial cells and is necessary for proper assembly of tight junctions. Mutation in this gene have been identified in patients with hypercholanemia. Alternate splicing results in multiple transcript variants.
• Uniprot ID: Q9UDY2
• Protein Accession #: NP_001164101.1
• Molecular Weight: 134 kDa