TJP1 Antibody (OABF00638)

Catalog No: OABF00638

Size:100UL

Formalin-fixed and paraffin embedded rat brain labeled with Anti- ZO-1 Polyclonal Antibody, Unconjugated (OABF00638) followed by conjugation to the secondary antibody and DAB staining

Formalin-fixed and paraffin embedded human testis labeled with Anti-ZO-1 Polyclonal Antibody, Unconjugated (OABF00638) at 1:250 followed by conjugation to the secondary antibody.

Image was kindly submitted by Sriram Srivatsa from Medical University of Vienna. Paraffin-embedded mouse colon stained with Rabbit Anti-ZO-1 Polyclonal Antibody (OABF00638) at 1:100.

Product Info

• Predicted Species Reactivity: Bovine|Chicken|Dog|Guinea Pig|Human|Mouse|Porcine|Rabbit|Rat
• Product Format: Liquid. Aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Flow cytometry|Immunocytochemistry|Immunofluorescence|Immunohistochemistry-Frozen|Immunohistochemistry-Paraffin|Western blot
• Additional Information: Subcellular location: Cytoplasm
• Reconstitution and Storage: -20°C
• Immunogen: KLH conjugated synthetic peptide derived from human ZO-1
• Purification: Protein A Purified
• Concentration: 1 ug/ul
• Intended Use: For research use only. Not intended for diagnostic or therapeutic use.
• Application Info: FC: 1:20 - 100
  IHC-P: : 1:100 - 500
  ICC: 1:50 - 200

Target Info

• Gene Symbol: TJP1
• Gene Full Name: tight junction protein 1
• Alias Symbols: Tight junction protein 1;tight junction protein ZO-1;ZO-1;zona occludens 1;Zona occludens protein 1;zonula occludens 1 protein;Zonula occludens protein 1.
• NCBI Gene Id: 7082
• Protein Name: Tight junction protein ZO-1
• Description of Target: TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:7798316, PubMed:9792688). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Necessary for lumenogenesis, and particularly efficient epithelial polarization and barrier formation (By similarity). Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (PubMed:21240187). Plays an important role in podosome formation and associated function, thus regulating cell adhesion and matrix remodeling (PubMed:20930113). With TJP2 and TJP3, participates to the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity).
• Uniprot ID: Q07157