TIRAP Antibody (OAPB00199)

Catalog No: OAPB00199 (Formerly GWB-62EBB9)

Size:100UG

Western blot analysis of TIRAP in MCF-7 cell lysate with TIRAP antibody at 4 ug/mL.

Immunohistochemistry of TIRAP in human heart tissue with TIRAP antibody at 20 ug/mL.

Product Info

• Predicted Species Reactivity: Human|Mouse
• Product Format: Liquid. TIRAP Antibody is supplied in PBS containing 0.02% sodium azide.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry-Paraffin|Western blot
  Buffer: Antibody is supplied in PBS containing 0.02% sodium azide.
• Reconstitution and Storage: TIRAP antibody can be stored at 4C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
• Immunogen: TIRAP antibody was raised against a peptide corresponding to amino acids near the middle of human TIRAP. The immunogen is located within amino acids 80 - 130 of TIRAP.
• Purification: Ion Exchange
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-TIRAP (OAPB00199) antibody is Catalog # OEPB02295
• Application Info: TIRAP antibody can be used for detection of TIRAP by Western blot at 4 ug/ml. (Optimal dilution should be determined by user)
• Reference: Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.;Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.;Janeway CA Jr and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.;O’Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.

Target Info

• Gene Symbol: TIRAP
• Gene Full Name: TIR domain containing adaptor protein
• Alias Symbols: adapter protein wyatt;adaptor protein Wyatt;BACTS1;Mal;MyD88 adapter-like protein;MyD88-2;toll/interleukin-1 receptor domain-containing adapter protein;toll-interleukin 1 receptor (TIR) domain containing adaptor protein;Toll-like receptor adaptor protein;wyatt.
• NCBI Gene Id: 114609
• Protein Name: TIR domain containing adaptor protein TIRAP [Homo sapiens]|Toll/interleukin-1 receptor domain-containing adapter protein
• Description of Target: Adapter involved in TLR2 and TLR4 signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha and interleukin-6.
• Uniprot ID: P58753
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/AAL05627
• Nucleotide Accession #: NM_001039661.1; NM_148910.2