TIGIT Antibody (OATA00270)

Catalog No: OATA00270

The 1G9 antibody reacts with mouse TIGIT (T cell Ig and ITIM domain), a 26 kDa member of the CD28 receptor family which is reported to regulate T cell receptor (TCR) activation. Within the CD28 family of receptors there are those which have co-stimulatory activity, such as CD28 and CTLA-4, as well as more recently identified receptors like TIGIT which are proposed to provide co-inhibitory signals. TIGIT is expressed and upregulated on activated T cells, and is also expressed on memory and regulatory T cells. Upon engagement by its ligands, CD112 and CD155, TIGIT signaling inhibits T cell proliferation and suppresses T cell responses, without triggering cell deletion. A second inhibitory effect of TIGIT signaling is the generation of immunoregulatory dendritic cells, which secrete IL-10 and TGF-beta to further inhibit T cell function.

Product Info

• Tested Species Reactivity: Mouse
• Product Format: Liquid 10 mM NaH₂PO₄, 150 mM NaCl, pH7.2
• Clonality: Monoclonal
• Clone: 1G9
• Isotype: Mouse IgG1, kappa
• Host: Mouse
• Application: FC, FN
• Additional Information: Endotoxin Level: ≤ 0.01 EU/ug, as determined by LAL assay
• Reconstitution and Storage: 2-8°C. Do not freeze.
• Purification: Purified from tissue culture supernatant via affinity chromatography
• Concentration: 2 mg/ml
• Specificity: TIGIT
• Application Info: Aviva tests all of our antibodies by flow cytometry. Citations may be provided as a resource for additional applications that have not been validated by Aviva - please consult Materials and Methods sections for additional details about the use of any product in these publications.
• Reference:

  Joller N, Peters A, Anderson AC, and Kuchroo VK. 2012. Immunol. Rev. 248(1):122-139. (Flow cytometry)

  Joller N, Hafler JP, Brynedal B, Kassam N, Spoerl S, Levin SD, Sharpe AH, and Kuchroo VK. 2011. J. Immunol. 186: 1338-1342. (Flow cytometry)

Target Info

• Gene Symbol: TIGIT
• Gene Full Name: T cell immunoreceptor with Ig and ITIM domains
• Alias Symbols: Vst, Vstm3
• NCBI Gene Id: 100043314
• Protein Name: T-cell immunoreceptor with Ig and ITIM domains
• Molecular Weight: 26 kDa