Catalog No: OOMC00060
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OOMC00060
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Tigecycline (OOMC00060)

Datasheets/ManualsPrintable datasheet for OOMC00060
Product Info
Product FormatPowder
Additional InformationCAS: 220620-09-7
Molecular Formula: C29H39N5O8
::Chemical Name: (4S,4aS,5aR,12aR)-9-[[2-(tert-Butylamino)acetyl]amino]-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
::Primary Activity: Antibiotic
::COVID-19 Rationale: Like Azithromycin, has off-target effect on mitochondrial ribosomes, components of which interact with the SARS-CoV-2 Nsp8 protein
Reconstitution and StorageSoluble in DMSO (up to at least 25 mg/ml). Store at -20C.
Purity> 98%
Reference 1) Greer (2006) Tigecycline (Tygacil): the first in the glycylcycline class of antibiotics; Proc. (Bayl. Univ. Med. Cent.) 19 155 2) Peterson (2008) A review of tigecycline – the first glycylcycline; Int. J. Antimicrob. Agents 32 Suppl 4 S215 3) Skrtic et al. (2011) Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia; Cancer Cell 20 674 4) Jia et al. (2016) Tigecyclin targets nonsmall cell lung cancer through inhibition of mitochondrial function; Fundam. Clin. Pharmacol. 30 297 5) Hu et al. (2016) Antibiotic drug tigecycline inhibits melanoma progression and metastasis in a p21CIP1/Waf1-dependent manner; Oncotarget 7 3171 6) D’Andrea et al. (2016) The mitochondrial translational machinery as a therapeutic target in Myc-driven lymphomas.; Oncotarget 7 72415 7) Chen et al. (2019) Inhibition of mitochondrial translation selectively targets osteosarcoma; Biochem. Biophys. Res. Commun. 515 9
Alias Symbols9-t-Butylglycylamidominocycline, GAR-936
Molecular Weight585.66 g/mol
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