Catalog No: OOMC00060
Price: $0.00
SKU
OOMC00060
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
Contact Us:
- Toll Free: 888-880-0001
- Phone: 858-552-6979
- Email: info@avivasysbio.com
Shipping Info:
- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
Datasheets/Manuals | Printable datasheet for OOMC00060 |
---|
Product Format | Powder |
---|---|
Additional Information | CAS: 220620-09-7 Molecular Formula: C29H39N5O8 |
:: | Chemical Name: (4S,4aS,5aR,12aR)-9-[[2-(tert-Butylamino)acetyl]amino]-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide |
:: | Primary Activity: Antibiotic |
:: | COVID-19 Rationale: Like Azithromycin, has off-target effect on mitochondrial ribosomes, components of which interact with the SARS-CoV-2 Nsp8 protein |
Reconstitution and Storage | Soluble in DMSO (up to at least 25 mg/ml). Store at -20C. |
Purity | > 98% |
Reference | 1) Greer (2006) Tigecycline (Tygacil): the first in the glycylcycline class of antibiotics; Proc. (Bayl. Univ. Med. Cent.) 19 155 2) Peterson (2008) A review of tigecycline – the first glycylcycline; Int. J. Antimicrob. Agents 32 Suppl 4 S215 3) Skrtic et al. (2011) Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia; Cancer Cell 20 674 4) Jia et al. (2016) Tigecyclin targets nonsmall cell lung cancer through inhibition of mitochondrial function; Fundam. Clin. Pharmacol. 30 297 5) Hu et al. (2016) Antibiotic drug tigecycline inhibits melanoma progression and metastasis in a p21CIP1/Waf1-dependent manner; Oncotarget 7 3171 6) D’Andrea et al. (2016) The mitochondrial translational machinery as a therapeutic target in Myc-driven lymphomas.; Oncotarget 7 72415 7) Chen et al. (2019) Inhibition of mitochondrial translation selectively targets osteosarcoma; Biochem. Biophys. Res. Commun. 515 9 |
Alias Symbols | 9-t-Butylglycylamidominocycline, GAR-936 |
---|---|
Molecular Weight | 585.66 g/mol |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
-
See our General FAQ page.
Write Your Own Review