THRA Antibody - middle region (ARP34780_P050)

Catalog No: ARP34780_P050

WB Suggested Anti-THRA Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:62500
Positive Control: Jurkat cell lysateThere is BioGPS gene expression data showing that THRA is expressed in Jurkat

WB Suggested Anti-THRA antibody Titration: 1 ug/mL
Sample Type: Human heart

Host: Mouse
Target Name: THRA
Sample Tissue: Mouse Heart
Antibody Dilution: 1ug/ml

Host: Mouse
Target Name: THRA
Sample Tissue: Mouse Spleen
Antibody Dilution: 1ug/ml

Host: Rabbit
Target: THRA
Positive control (+): Human Ovary (OV)
Negative control (-): Human stomach (ST)
Antibody concentration: 0.5ug/ml

Product Info

• Tested Species Reactivity: Human, Mouse
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Sheep, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human THRA
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Sheep: 100%; Zebrafish: 100%
• Peptide Sequence: Synthetic peptide located within the following region: DQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVV
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-THRA (ARP34780_P050) antibody is Catalog # AAP34780 (Previous Catalog # AAPP05974)
• Sample Type Confirmation:

  There is BioGPS gene expression data showing that THRA is expressed in Jurkat

• Publications:

  Kiss-Toth, E., Harlock, E., Lath, D., Quertermous, T. & Wilkinson, J. M. A TNF variant that associates with susceptibility to musculoskeletal disease modulates thyroid hormone receptor binding to control promoter activation. PLoS One 8, e76034 (2013). 24069456

Target Info

• Gene Symbol: THRA
• Gene Full Name: Thyroid hormone receptor, alpha
• Alias Symbols: AR7, EAR7, ERBA, CHNG6, ERBA1, NR1A1, THRA1, THRA2, ERB-T-1, c-ERBA-1
• NCBI Gene Id: 7067
• Protein Name: Thyroid hormone receptor alpha
• Description of Target: The THRA gene encodes a protein that is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone.
• Uniprot ID: P10827
• Protein Accession #: NP_003241
• Nucleotide Accession #: NM_003250
• Protein Size (# AA): 490
• Molecular Weight: 55kDa
• Protein Interactions: L3MBTL3; AMOTL2; RANBP9; NCOR1; PTGES3; THRA; RXRA; FOXJ1; CLIC1; C1D; NCOR2; BUB3; tat; GTF2B; ARID5A; SUMO1; SUMO3; MED1; NRIP1; MED21; CDK7; MED25; RGN; CUL1; SEPP1; TBL1XR1; HDAC3; SMC1A; XRCC5; TBL1X; PRKDC; LIG3; HSPA4; GPS2; XRCC6; PARP1; EMD; GRIP