TGFBR2 Recombinant Protein (OPCD07394)

Catalog No: OPCD07394

TGFBR2 Recombinant Protein (OPCD07394) using SDS-PAGE

TGFBR2 Recombinant Protein (OPCD07394) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ile209-Thr590
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: >95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Tgfbr2
• Gene Full Name: transforming growth factor, beta receptor II
• Alias Symbols: 1110020H15Rik;AU042018;DNIIR;RIIDN;Tbet;Tbeta;TbetaRII;TbetaR-II;TBR;TBR-II;TGF-beta receptor II;TGF-beta receptor type II;TGF-beta receptor type-2;TGF-beta type II receptor;TGFR-2;transforming growth factor-beta receptor type II.
• NCBI Gene Id: 21813
• Protein Name: TGF-beta receptor type-2
• Description of Target: Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways (By similarity).
• Uniprot ID: Q62312
• Protein Accession #: NP_033397.3
• Nucleotide Accession #: NM_009371.3
• Protein Size (# AA): Ile209~Thr590
• Molecular Weight: 47.5kDa