TGFBR2 Protein (OPPA02170)

Catalog No: OPPA02170 (Formerly GWB-FE5DB3)

Size:2UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: Lyophilized from a 0.2 um filtered solution in buffer containing 150mM NaCl & 50mM sodium phosphate buffer pH-7.5. Physical appearance: Sterile Filtered White lyophilized (freeze-dried) powder.
• Host: E. Coli
• Additional Information: Solubility: It is recommended to reconstitute the lyophilized TGFBR2 in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
  Activity: In ELISA assay, concentrations 0.5-1 ug/ml can be used for TGF-beta measurements
  Product Introduction: TGFBR2 is part of the Ser/Thr protein kinase family and the TGFB receptor subfamily. TGFBR2 is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in TGFBR2 gene have been associated with Marfan syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. TGFBR2 expression is increased in oral squamous cell carcinoma cells. TGFBR2 attenuates the biological activities of TGF-beta in colorectal cancer. TGFBR2 expression is decreased by IL-1beta while inducing Sp3 via NFkappaB. TGFB2 and TGFBR2 are involved in the antiestrogenic activity of tamoxifen metabolites in breast cancer.
  Product Description: TGFBR2 Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain encoding 133 amino acids (27-159 a.a.), the extracellular domain of TGFBR2, having a molecular mass of 15.1 kDa.TGFBR2 is purified by proprietary chromatographic techniques
• Reconstitution and Storage: Lyophilized TGFBR2 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution TGFBR2 should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
• Purity: Greater than 97.0% as determined by SDS-PAGE.
• Peptide Sequence: HVQK SVNNDMIVTD NNGAVKFPQL CKFCDVRFST CDNQKSCMSN CSITSICEKP QEVCVAVWRK NDENITLETV CHDPKLPYHD FILEDAASPK CIMKEKKKPG ETFFMCSCSS DECNDNIIFS EEYNTSNPD

Target Info

• Gene Symbol: TGFBR2
• Alias Symbols: AAT3, FAA3, LDS2, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TBRII, TBR-ii, TGFR-2, TGFbeta-RII
• NCBI Gene Id: 7048
• Protein Name: TGF-beta receptor type-2
• Description of Target: Recombinant Human Transforming Growth Factor Beta Receptor II
• Uniprot ID: P37173
• Protein Accession #: NP_001020018.1
• Protein Size (# AA): Recombinant