TGFBR2 Antibody (Phospho-Ser225) (OASG07146)

Catalog No: OASG07146

Size:100 uL

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid. 1 mg/mL in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: IHC
• Reconstitution and Storage: Store at -20C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human TGFBeta RII around the phosphorylation site of S225. Location: 160-240aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Ser225
• Specificity: Phospho-TGFBeta RII (S225) Polyclonal Antibody detects endogenous levels of TGFBeta RII protein only when phosphorylated at S225.
• Application Info: IHC 1:100-1:300; ELISA 1:10000;

Target Info

• Gene Symbol: TGFBR2
• Gene Full Name: transforming growth factor, beta receptor II (70/80kDa)
• Alias Symbols: AAT3, FAA3, LDS2, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TBRII, TBR-ii, TGFR-2, TGFbeta-RII
• NCBI Gene Id: 7048; 21813;
• Description of Target: This gene encodes a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The encoded protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternatively spliced transcript variants encoding different isoforms have been characterized.
• Uniprot ID: P37173, Q62312
• Molecular Weight: 65 kDa