TGFBR2 Antibody - N-terminal region : FITC (ARP44743_T100-FITC)

Catalog No: ARP44743_T100-FITC

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Goat, Pig, Rabbit
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: FITC: Fluorescein Isothiocyanate
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human TGFBR2
• Predicted Homology Based on Immunogen Sequence: Cow: 93%; Goat: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 100%; Rat: 93%;
• Peptide Sequence: Synthetic peptide located within the following region: MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDVEMEAQKDEIICPSCNRT
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-TGFBR2 (ARP44743_T100-FITC) antibody is Catalog # AAP44743 (Previous Catalog # AAPP12219)
• Sample Type Confirmation:

  TGFBR2 is strongly supported by BioGPS gene expression data to be expressed in HepG2

• Reference: Song,K., (2006) J. Biol. Chem. 281 (12), 7765-7774

Target Info

• Gene Symbol: TGFBR2
• Gene Full Name: Transforming growth factor, beta receptor II (70/80kDa)
• Alias Symbols: AAT3, FAA3, LDS2, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TBRII, TBR-ii, TGFR-2, TGFbeta-RII
• NCBI Gene Id: 7048
• Protein Name: TGF-beta receptor type-2
• Description of Target: TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in its gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors.This gene is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It encodes a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein and binds TGF-beta. This receptor/ligand complex phosphorylates proteins which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Uniprot ID: P37173
• Protein Accession #: NP_003233
• Nucleotide Accession #: NM_003242
• Protein Size (# AA): 567
• Molecular Weight: 62kDa
• Protein Interactions: TRAF4; NRP1; NRP2; TGFB1; TERT; PEG10; ENG; GOPC; IQGAP1; UBC; RCVRN; PDGFRA; APP; TGFBR1; MAP3K7; PAK1; OCLN; SMAD7; CDC42; Hsp90aa1; KCNK18; FBXO34; PPP1R16B; OXSR1; ARHGEF6; TRAF6; TSC22D1; SMURF1; OSR1; TCTEX1D4; SNX6; TSSK1B; TGFBRAP1; TRAP1; STRAP;