- Toll Free: 888-880-0001
- Phone: 858-552-6979
- Email: info@avivasysbio.com
- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
Datasheets/Manuals | Printable datasheet for anti-TGFBR2 (ARP44743_T100) antibody |
---|
Tested Species Reactivity | Human, Mouse | ||||||
---|---|---|---|---|---|---|---|
Predicted Species Reactivity | Human, Mouse, Rat, Cow, Goat, Pig, Rabbit | ||||||
Product Format | Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose. | ||||||
Clonality | Polyclonal | ||||||
Host | Rabbit | ||||||
Application | WB | ||||||
Reconstitution and Storage | For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles. | ||||||
Immunogen | The immunogen is a synthetic peptide directed towards the N terminal region of human TGFBR2 | ||||||
Purification | Protein A purified | ||||||
Predicted Homology Based on Immunogen Sequence | Cow: 93%; Goat: 93%; Human: 100%; Mouse: 93%; Pig: 93%; Rabbit: 100%; Rat: 93%; | ||||||
Peptide Sequence | Synthetic peptide located within the following region: MGRGLLRGLWPLHIVLWTRIASTIPPHVQKSDVEMEAQKDEIICPSCNRT | ||||||
Concentration | 1.0 mg/ml | ||||||
Blocking Peptide | For anti-TGFBR2 (ARP44743_T100) antibody is Catalog # AAP44743 (Previous Catalog # AAPP12219) | ||||||
Sample Type Confirmation | TGFBR2 is strongly supported by BioGPS gene expression data to be expressed in HepG2 | ||||||
Enhanced Validation |
| ||||||
Reference | Song,K., (2006) J. Biol. Chem. 281 (12), 7765-7774 |
Gene Symbol | TGFBR2 |
---|---|
Gene Full Name | Transforming growth factor, beta receptor II (70/80kDa) |
Alias Symbols | AAT3, FAA3, LDS2, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TBRII, TBR-ii, TGFR-2, TGFbeta-RII |
NCBI Gene Id | 7048 |
Protein Name | TGF-beta receptor type-2 |
Description of Target | TGFBR2 is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. The protein is a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein, and binds TGF-beta. This receptor/ligand complex phosphorylates proteins, which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in its gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors.This gene is a member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It encodes a transmembrane protein that has a protein kinase domain, forms a heterodimeric complex with another receptor protein and binds TGF-beta. This receptor/ligand complex phosphorylates proteins which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation. Mutations in this gene have been associated with Marfan Syndrome, Loeys-Deitz Aortic Aneurysm Syndrome, and the development of various types of tumors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
Uniprot ID | P37173 |
Protein Accession # | NP_003233 |
Nucleotide Accession # | NM_003242 |
Protein Size (# AA) | 567 |
Molecular Weight | 65 kDa |
Protein Interactions | TRAF4; NRP1; NRP2; TGFB1; TERT; PEG10; ENG; GOPC; IQGAP1; UBC; RCVRN; PDGFRA; APP; TGFBR1; MAP3K7; PAK1; OCLN; SMAD7; CDC42; Hsp90aa1; KCNK18; FBXO34; PPP1R16B; OXSR1; ARHGEF6; TRAF6; TSC22D1; SMURF1; OSR1; TCTEX1D4; SNX6; TSSK1B; TGFBRAP1; TRAP1; STRAP; |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
-
See our General FAQ page.
-
What is the species homology for "TGFBR2 Antibody - N-terminal region (ARP44743_T100)"?
The tested species reactivity for this item is "Human, Mouse". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Goat, Pig, Rabbit".
-
How long will it take to receive "TGFBR2 Antibody - N-terminal region (ARP44743_T100)"?
This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".
-
What buffer format is "TGFBR2 Antibody - N-terminal region (ARP44743_T100)" provided in?
This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "TGFBR2 Antibody - N-terminal region (ARP44743_T100)"?
This target may also be called "AAT3, FAA3, LDS2, MFS2, RIIC, LDS1B, LDS2B, TAAD2, TBRII, TBR-ii, TGFR-2, TGFbeta-RII" in publications.
-
What is the shipping cost for "TGFBR2 Antibody - N-terminal region (ARP44743_T100)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
-
What is the guarantee for "TGFBR2 Antibody - N-terminal region (ARP44743_T100)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
-
Can I get bulk pricing for "TGFBR2 Antibody - N-terminal region (ARP44743_T100)"?
You can get bulk pricing for this item by going here.
-
What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "65 kDa".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "TGFBR2 Antibody - N-terminal region (ARP44743_T100)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
-
What are positive controls for "TGFBR2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What are negative controls for "TGFBR2"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
-
What other proteins interact with "TGFBR2"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
-
What biological processes are associated with "TGFBR2"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
-
What cellular components are associated with "TGFBR2"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
-
What protein functions are associated with "TGFBR2"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.