TGFB1 Recombinant Protein (OPCD07373)

Catalog No: OPCD07373

TGFB1 Recombinant Protein (OPCD07373) using SDS-PAGE

TGFB1 Recombinant Protein (OPCD07373) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Isoelectric Point: 8.4
  Subcellular Location: Secreted, Extracellular matrix
  Residues: Ala279-Ser390
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 97%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Tgfb1
• Gene Full Name: transforming growth factor, beta 1
• Alias Symbols: Tgfb;Tgfb-1;TGFbeta;TGF-beta;TGFbeta1;TGF-beta1;transforming growth factor beta-1 proprotein.
• NCBI Gene Id: 21803
• Protein Name: Transforming growth factor beta-1
• Description of Target: Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts (PubMed:22781750). Stimulates sustained production of collagen through the activation of CREB3L1 by regulated intramembrane proteolysis (RIP) (By similarity). Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (PubMed:18368049). Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity).
• Uniprot ID: P04202
• Protein Accession #: NP_035707.1
• Nucleotide Accession #: NM_011577.2
• Protein Size (# AA): Ala279~Ser390
• Molecular Weight: 16kDa