TGF b 1 Protein (OPPA01796)

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Technical Documents

Datasheets/Manuals	Printable datasheet for OPPA01796

Product Info

Product Info
Product Format	Each ug TGF-Beta1 protein contains 10 ug Bovine Serum Albumin as a preservative. Physical appearance: Sterile Filtered lyophilized powder.
Host	Human Platelets
Additional Information	Solubility: It is recommended to reconstitute 5 ug lyophilized TGF-beta 1 in sterile 100 ul 5mM HCl, which can then be further diluted to the desired aliquot to 1ml of PBS containing 2mg Bovine Serum Albumin.
::	Biological Activity: Stimulates the growth of NRK-1 cells in soft agar at concentrations ranging from 0.1 to 5ng/ml. Effective concentration ranges must be experimentally determined. Purified EGF and/or TGF-alpha at concentrations of at least 2ng/ml must be present for observation of the biological activity.
::	Product Introduction: Transforming growth factor betas (TGF Betas) mediate many cell-cell interactions that occur during embryonic development. Three TGFBetas have been identified in mammals. TGFBeta1, TGFBeta2 and TGFBeta3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecule. Product Description: Human Transforming Growth Factor-beta 1 purified from Human Platelets having a molecular mass of 25kDa.The TGF-b 1 is purified by proprietary chromatographic techniques.
Reconstitution and Storage	Lyophilized TGF-beta 1 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution TGF-beta 1 should be stored at 4C between 2-7 days and for future use below -18C. DO NOT RECONSTITE WITH NEUTRAL BUFFERS. DO NOT USE GLASS IMPLEMENTS OR EXTENSIVE MANIPULATIONS. PREVENT FREEZE THAW CYCLES.
Purity	Greater than 97.0%.

Target Info

Gene Symbol	TGF b 1
Alias Symbols	CED, LAP, DPD1, TGFB, IBDIMDE, TGFbeta, TGF-beta1
NCBI Gene Id	7040
Protein Name	Transforming growth factor beta-1
Description of Target	Human Transforming Growth Factor-Beta 1
Uniprot ID	P01137
Protein Accession #	NP_000651.3

Protocols & Data

Protocol:

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Protein interactions

Name	# of Products
ACVRL1	23
APP	257
BGN	69
BMP2	50
BMP3	13
CCL3	31
COL2A1	112
CTGF	62
DAXX	194
DCN	101
DPT	15
EIF3I	172
ENG	59
EPS15	106
FCN1	11
FKBP1A	46
FMOD	18
FNTA	18
ITGAV	127
ITGB6	32
ITGB8	26
LAMB1	26
LTBP1	34
LTBP3	21
LTBP4	10
MMP2	142
PZP	66
SDC2	84
SMAD2	408
SMAD3	511
SPARC	118
TGFB1	144
TGFB2	68
TGFBR1	269
TGFBR2	93
TGFBR3	53
TGFBRAP1	24
THBS1	221
VASN	18
VTN	147
YWHAE	312

Biological pathways

Name	# of Products
Active induction of host immune response by virus	8
ATP biosynthetic process	39
Cell cycle arrest	360
Cell growth	88
Cell-cell junction organization	27
Chondrocyte differentiation	48
Connective tissue replacement involved in inflammatory response wound healing	22
Epidermal growth factor receptor signaling pathway	240
Evasion of host defenses by virus	14
Hemopoietic progenitor cell differentiation	25
Induction of apoptosis	395
Lymph node development	41
Macrophage derived foam cell differentiation	9
Mitotic cell cycle G1/S transition checkpoint	27
Negative regulation of blood vessel endothelial cell migration	49
Negative regulation of cell growth	201
Negative regulation of cell-cell adhesion	31
Negative regulation of DNA replication	38
Negative regulation of epithelial cell proliferation	52
Negative regulation of fat cell differentiation	103
Negative regulation of macrophage cytokine production	21
Negative regulation of mitotic cell cycle	44
Negative regulation of myoblast differentiation	24
Negative regulation of protein phosphorylation	63
Negative regulation of skeletal muscle tissue development	9
Ossification involved in bone remodeling	17
Pathway-restricted SMAD protein phosphorylation	40
Platelet activation	875
Platelet degranulation	443
Positive regulation of blood vessel endothelial cell migration	76
Positive regulation of bone mineralization	99
Positive regulation of cell division	223
Positive regulation of chemotaxis	23
Positive regulation of collagen biosynthetic process	46
Positive regulation of epithelial to mesenchymal transition	70
Positive regulation of fibroblast migration	11
Positive regulation of interleukin-17 production	72
Positive regulation of isotype switching to IgA isotypes	12
Positive regulation of MAP kinase activity	147
Positive regulation of pathway-restricted SMAD protein phosphorylation	78
Positive regulation of peptidyl-serine phosphorylation	168
Positive regulation of peptidyl-threonine phosphorylation	35
Positive regulation of phosphatidylinositol 3-kinase activity	98
Positive regulation of protein dephosphorylation	20
Positive regulation of protein kinase B signaling cascade	183
Positive regulation of protein secretion	43
Positive regulation of SMAD protein import into nucleus	41
Positive regulation of transcription from RNA polymerase II promoter	1210
Protein export from nucleus	39
Protein import into nucleus, translocation	102
Receptor catabolic process	12
Regulation of DNA binding	13
Regulation of transforming growth factor beta receptor signaling pathway	51
Response to cholesterol	24
Response to estradiol stimulus	85
Response to progesterone stimulus	40
Salivary gland morphogenesis	18
SMAD protein complex assembly	45
SMAD protein import into nucleus	30
Transforming growth factor beta receptor signaling pathway	171
Viral infectious cycle	29

Biological process

Name	# of Products
Active induction of host immune response by virus	2
Adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	4
Aging	124
ATP biosynthetic process	28
Blood coagulation	396
Branch elongation involved in mammary gland duct branching	4
Cell cycle arrest	142
Cell death	133
Cell-cell junction organization	58
Cellular calcium ion homeostasis	76
Cellular response to dexamethasone stimulus	16
Cellular response to growth factor stimulus	63
Cellular response to organic cyclic compound	58
Chondrocyte differentiation	37
Connective tissue replacement involved in inflammatory response wound healing	3
Defense response to fungus, incompatible interaction	3
Digestive tract development	26
Embryo development	133
Endoderm development	33
Epidermal growth factor receptor signaling pathway	124
Evasion of host defenses by virus	6
Extracellular matrix assembly	4
Face morphogenesis	40
Female pregnancy	73
Frontal suture morphogenesis	6
Germ cell migration	17
Hemopoietic progenitor cell differentiation	18
Induction of apoptosis	226
Inflammatory response	339
Inner ear development	38
Lens fiber cell differentiation	14
Lipopolysaccharide-mediated signaling pathway	48
Lymph node development	27
Macrophage derived foam cell differentiation	4
Mammary gland branching involved in thelarche	7
Mammary gland development	47
MAPK cascade	105
Mitotic cell cycle G1/S transition checkpoint	15
Mononuclear cell proliferation	5
Morphogenesis of a branching structure	11
Myelination	30
Myeloid dendritic cell differentiation	19
Negative regulation of blood vessel endothelial cell migration	16
Negative regulation of cell cycle	50
Negative regulation of cell growth	119
Negative regulation of cell proliferation	375
Negative regulation of cell-cell adhesion	13
Negative regulation of DNA replication	25
Negative regulation of epithelial cell proliferation	44
Negative regulation of fat cell differentiation	35
Negative regulation of immune response	16
Negative regulation of macrophage cytokine production	9
Negative regulation of mitotic cell cycle	19
Negative regulation of myoblast differentiation	12
Negative regulation of neuroblast proliferation	11
Negative regulation of ossification	21
Negative regulation of phagocytosis	9
Negative regulation of protein phosphorylation	40
Negative regulation of release of sequestered calcium ion into cytosol	3
Negative regulation of skeletal muscle tissue development	11
Negative regulation of T cell proliferation	36
Negative regulation of transcription from RNA polymerase II promoter	574
Negative regulation of transcription, DNA-dependent	520
Organ regeneration	59
Ossification involved in bone remodeling	6
Pathway-restricted SMAD protein phosphorylation	18
Phosphate-containing compound metabolic process	23
Platelet activation	202
Platelet degranulation	78
Positive regulation of blood vessel endothelial cell migration	24
Positive regulation of bone mineralization	35
Positive regulation of branching involved in ureteric bud morphogenesis	26
Positive regulation of cell cycle arrest	16
Positive regulation of cell division	67
Positive regulation of cell proliferation	483
Positive regulation of cellular protein metabolic process	20
Positive regulation of chemotaxis	14

Cellular components

Name	# of Products
Axon	179
Cell surface	369
Cytoplasm	4549
Extracellular region	1573
Extracellular space	884
Golgi lumen	35
Microvillus	39
Neuronal cell body	203
Nucleus	4914
Platelet alpha granule lumen	42
Proteinaceous extracellular matrix	159
Secretory granule	77

Protein function

Name	# of Products
Enzyme binding	898
Eukaryotic cell surface binding	205
Growth factor activity	831
Protein binding	12191
Protein heterodimerization activity	1132
Protein homodimerization activity	1852
Protein N-terminus binding	253
Type II transforming growth factor beta receptor binding	36

Diseases

Name	# of Products
Disease mutation	5332

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TGF b 1 Protein (OPPA02090)
Catalog #: OPPA02090

Format: Liquid 10mM Sodium Citrate (pH 3.5) and 10% glycerol
Physical Appearance: Sterile Filtered colorless solution

Size: 2UG

Price: $75.00

TGF b 1 Protein (OPPA01796)

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