TFE3 Antibody - C-terminal region (OAAB13847)

Catalog No: OAAB13847

Size:400ul

TFE3 Antibody (C-term) (Cat. # OAAB13847) western blot analysis in mouse kidney tissue lysates (35ug/lane).This demonstrates the TFE3 Antibody detected the TFE3 protein (arrow).

Product Info

• Predicted Species Reactivity: Human, Mouse, Cow
• Product Format: Liquid. PBS with 0.09% (W/V) sodium azide.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB
  Cellular Location: Nucleus.
  Tissue Location: Ubiquitous in fetal and adult tissues.
  
• Reconstitution and Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This TFE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 489-516 amino acids from the C-terminal region of human TFE3.
• Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.
• Predicted Homology Based on Immunogen Sequence: Cow; Human; Mouse
• Concentration: Varies by lot. See vial for concentration.
• Intended Use: TFE3 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
• Application Info: WB: 1:1000

Target Info

• Gene Symbol: TFE3
• Alias Symbols: TFEA, RCCP2, RCCX1, bHLHe33
• NCBI Gene Id: 7030
• Protein Name: Transcription factor E3
• Description of Target: The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1); it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.
• Uniprot ID: P19532
• Protein Accession #: NP_006512.2
• Molecular Weight: 61.5 kDa