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Catalog No: OPCD07333
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OPCD07333
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Datasheets/ManualsPrintable datasheet for TFAM Recombinant Protein (OPCD07333)
Product Info
Predicted Species ReactivityMouse|Mus musculus
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Ser43-His243
::Subcellular Location: Mitochondrion
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 90%
SourceE.coli
TagN-terminal His and GST Tag
Gene SymbolTfam
Gene Full Nametranscription factor A, mitochondrial
Alias SymbolsAI661103;Hmgt;Hmgts;mtTF;mtTFA;testis-specific high mobility group protein;testis-specific HMG-box protein m-tsHMG;transcription factor A, mitochondrial;tsHM;tsHMG;TS-HMG.
NCBI Gene Id21780
Protein NameTranscription factor A, mitochondrial
Description of TargetIsoform Mitochondrial binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA. Isoform Nuclear may also function as a transcriptional activator or may have a structural role in the compaction of nuclear DNA during spermatogenesis.
Uniprot IDP40630
Protein Accession #NP_033386.1
Nucleotide Accession #NM_009360.4
Protein Size (# AA)Ser43~His243
Molecular Weight53kDa
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