Catalog No: OAEB00839 (Formerly GWB-EV0686)
Size:100UG
Price: $379.00
SKU
OAEB00839
Availability: Domestic: within 1-2 week delivery | International: 1-2 weeks
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  • $55: Antibody & Protein in US
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Datasheets/ManualsPrintable datasheet for TET2 Antibody (OAEB00839)
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityDog|Human|Mouse
Product FormatSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.
ClonalityPolyclonal
HostGoat
ApplicationIHC
Reconstitution and StorageAliquot and store at -20°C. Minimize freezing and thawing.
ImmunogenTET2
PurificationAmmonium Sulfate Precipitated; Affinity Purified
Predicted Homology Based on Immunogen SequenceHuman, Mouse, Dog
Peptide SequenceC-PHPQSNNDQQREGSF
Concentration0.5 mg/ml
SpecificityThis antibody is expected to recognize both reported isoforms (NP_001120680.1; NP_060098.3).
Application InfoP-ELISA: Antibody detection limit dilution 1:16000
IHC: In paraffin embedded Human Spleen shows nuclear staining in select splenocytes. Recommended concentration: 2-6 ug/ml.
ReferenceLangemeijer SM, Kuiper RP, Berends M, Knops R, Aslanyan MG, Massop M, Stevens-Linders E, van Hoogen P, van Kessel AG, Raymakers RA, Kamping EJ, Verhoef GE, Verburgh E, Hagemeijer A, Vandenberghe P, de Witte T, van der Reijden BA, Jansen JH,
Acquired mutations in TET2 are common in myelodysplastic syndromes.
Nature Gen. 2009 Jul 41 (7): 838-42. PMID: 19483684
Publications

Reduction of global 5-hydroxymethylcytosine is a poor prognostic factor in breast cancer patients, especially for an ER/PR-negative subtype. Breast Cancer Res. Treat. 153, 219-34 (2015). 26253945

Ten-eleven translocation 1 dysfunction reduces 5-hydroxymethylcytosine expression levels in gastric cancer cells. Oncol Lett. 15, 278-284 (2018). 29285192

Description
Gene SymbolTet2|TET2
Gene Full Nametet methylcytosine dioxygenase 2
Alias SymbolsAyu17-44;Ayu17-449;E130014J05Rik;IMD75;KIAA1546;MDS;methylcytosine dioxygenase TET2;mKIAA1546;probable methylcytosine dioxygenase TET2;ten-eleven translocation 2;tet oncogene 2;tet oncogene family member 2.
NCBI Gene Id214133|54790
Protein NameMethylcytosine dioxygenase TET2
Uniprot IDQ6N021
Protein Accession #NP_001120680.1
Molecular Weight224; 130
  1. What is the species homology for "TET2 Antibody (OAEB00839)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Dog|Human|Mouse".

  2. How long will it take to receive "TET2 Antibody (OAEB00839)"?

    This item is available "Domestic: within 1-2 week delivery | International: 1-2 weeks".

  3. What buffer format is "TET2 Antibody (OAEB00839)" provided in?

    This item is provided in "Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. Aliquot and store at -20°C. Minimize freezing and thawing.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "TET2 Antibody (OAEB00839)"?

    This target may also be called "Ayu17-44;Ayu17-449;E130014J05Rik;IMD75;KIAA1546;MDS;methylcytosine dioxygenase TET2;mKIAA1546;probable methylcytosine dioxygenase TET2;ten-eleven translocation 2;tet oncogene 2;tet oncogene family member 2." in publications.

  5. What is the shipping cost for "TET2 Antibody (OAEB00839)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "TET2 Antibody (OAEB00839)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "TET2 Antibody (OAEB00839)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "224; 130".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "TET2 Antibody (OAEB00839)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "Tet2|TET2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "Tet2|TET2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "Tet2|TET2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "Tet2|TET2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "Tet2|TET2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "Tet2|TET2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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