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TERT Antibody - middle region : FITC (ARP72509_P050-FITC)

100 ul
$289.00
In Stock
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Conjugation Options

ARP72509_P050 Unconjugated

ARP72509_P050-HRP Conjugated

ARP72509_P050-Biotin Conjugated

Gene Symbol:
TERT
NCBI Gene Id:
7015
Swissprot Id:
O14746-2
Alias Symbols:
TERT, EST2, TCS1, TRT,
Replacement Item:
This antibody may replace item sc-156050 from Santa Cruz Biotechnology.
Description of Target:
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
Protein Size (# AA):
807
Molecular Weight:
88kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express TERT.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express TERT.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of Human TERT
Predicted Species Reactivity:
Human
Peptide Sequence:
Synthetic peptide located within the following region: RQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSL
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer.
Reconstitution and Storage:
All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
Concentration:
1 mg/ml
Protein Interactions:
TPP1; AKT1; HSP90AA1; HSPA4; DDX51; C19orf40; STEAP4; PBK; PHF20L1; TIMM21; PABPC1; SERBP1; SLC7A11; U2SURP; CCT5; ACAA2; TUBA1B; DYNLL1; UBE2D3; TGFBR2; PPIA; PFDN1; IREB2; GLA; ENO1; EIF2S1; ATP5B; ANXA2; CIB1; UBC; vpr; VPRBP; RUVBL2; RUVBL1; TERC; DKC
Blocking Peptide:
For anti-TERT (ARP72509_P050-FITC) antibody is Catalog # AAP72509
Datasheets/Manuals:
Printable datasheet for anti-TERT (ARP72509_P050-FITC) antibody
Conjugation:
FITC (FAM): Excitation 495 nm/ Emission 520 nm

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