TERT Antibody - middle region (ARP72509_P050)

Catalog No: ARP72509_P050

Host: Rabbit
Target Name: TERT
Sample Type: NCI-H226 Whole Cell lysates
Antibody Dilution: 1.0ug/ml

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human TERT
• Purification: Affinity Purified
• Peptide Sequence: Synthetic peptide located within the following region: RQHHAGPPSTSRPPRPWDTPCPPVYAETKHFLYSSGDKEQLRPSFLLSSL
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-TERT (ARP72509_P050) antibody is Catalog # AAP72509

Target Info

• Gene Symbol: TERT
• Alias Symbols: TP2, TRT, CMM9, EST2, TCS1, hTRT, DKCA2, DKCB4, hEST2, PFBMFT1
• NCBI Gene Id: 7015
• Description of Target: Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.
• Uniprot ID: O14746-2
• Protein Size (# AA): 807
• Molecular Weight: 88kDa
• Protein Interactions: TPP1; AKT1; HSP90AA1; HSPA4; DDX51; C19orf40; STEAP4; PBK; PHF20L1; TIMM21; PABPC1; SERBP1; SLC7A11; U2SURP; CCT5; ACAA2; TUBA1B; DYNLL1; UBE2D3; TGFBR2; PPIA; PFDN1; IREB2; GLA; ENO1; EIF2S1; ATP5B; ANXA2; CIB1; UBC; vpr; VPRBP; RUVBL2; RUVBL1; TERC; DKC