TCF7L2 Antibody - middle region (ARP33414_P050)

Catalog No: ARP33414_P050

WB Suggested Anti-TCF7L2 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: 1:2500
Positive Control: Human Muscle

Hum. Fetal Heart

Hum. Fetal Lung

Hum. Fetal Liver

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TCF7L2
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 92%; Dog: 92%; Guinea Pig: 92%; Horse: 92%; Human: 92%; Mouse: 92%; Rabbit: 92%; Rat: 92%; Zebrafish: 92%
• Peptide Sequence: Synthetic peptide located within the following region: GGFRHPYPTALTVNASMSRFPPHMVPPHHTLHTTGIPHPAIVTPTVKQES
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-TCF7L2 (ARP33414_P050) antibody is Catalog # AAP33414 (Previous Catalog # AAPP04460)
• Reference: Ren,Q., (2008) Diabetologia 51 (7), 1146-1152

Target Info

• Gene Symbol: TCF7L2
• Gene Full Name: Transcription factor 7-like 2 (T-cell specific, HMG-box)
• Alias Symbols: TCF4, TCF-4
• NCBI Gene Id: 6934
• Protein Name: TCF7L2 protein EMBL CAG38811.1
• Description of Target: The TCL7L2 is a high mobility group (HMG) box-containing transcription factor implicated in blood glucose homeostasis. The study of Yi et al. suggested that TCL7L2 acts through regulation of proglucagon through repression of the proglucagon gene in enteroendocrine cells via the Wnt signaling pathway. The TCL7L2 gene product is a high mobility group (HMG) box-containing transcription factor implicated in blood glucose homeostasis. The study of Yi et al. (2005) [PubMed 15525634] suggested that TCL7L2 acts through regulation of proglucagon (MIM 138030) through repression of the proglucagon gene in enteroendocrine cells via the Wnt signaling pathway.[supplied by OMIM]. Sequence Note: This gene (TCF7L2, alias TCF-4) is distinct from TCF4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-202 DA473655.1 1-202 203-251 Y11306.2 3-51 252-1252 AK225809.1 256-1256 1253-1305 Y11306.2 1053-1105 1306-1756 AK225809.1 1310-1760 1757-1811 Y11306.2 1557-1611 1812-2652 AK225809.1 1765-2605
• Uniprot ID: Q6FHW4
• Protein Accession #: NP_110383
• Nucleotide Accession #: NM_030756
• Protein Size (# AA): 596
• Molecular Weight: 65kDa
• Protein Interactions: UBC; FBLN1; UBE2I; PSMA3; MAD2L2; ZBTB33; DAXX; CTNNB1; ELAVL1; PARP1; XRCC5; SUMO2; XRCC6; NR5A1; EP300; CEBPA; CTBP1; DAZAP2; CTNNBIP1; JUP; CSNK2A2; CSNK2A1; PSEN1; NLK; RAC1;