Search Antibody, Protein, and ELISA Kit Solutions

TBP Antibody (OADC00242)

100ug
$319.00
In Stock
Request Bulk Order Quote

Predicted Species Reactivity:
Human
Product Format:
Liquid. Provided in PBS containing 0.05% azide; purified by ammonium sulphate precipitation followed by dialysis.
Clonality:
Monoclonal
Isotype:
IgG1
Host:
Mouse
Conjugation:
Unconjugated
Application:
CHIP
Reconstitution and Storage:
Store at -20C. Avoid repeated freeze/thaw cycles.
Replacement Item:
This antibody may replace item sc-124002 from Santa Cruz Biotechnology.
Purification:
Protein A/G purified
Predicted Homology Based on Immunogen Sequence:
Mouse
Concentration:
8 mg/mL
Datasheets/Manuals:
Printable datasheet for anti-TBP (OADC00242) antibody
Preservative:
0.05% Sodium Azide
Specificity:
Monoclonal antibody raised in mouse against the amino-terminal domain of human TBP (TATA box binding protein).
Application Info:
CHIP: 4 - 5 ug/IP
Gene Symbol:
TBP
Official Gene Full Name:
TATA-box binding protein
Alias Symbols:
HDL4, GTF2D, SCA17, TFIID, GTF2D1
NCBI Gene Id:
6908;
Protein Name:
TATA-box-binding protein
Description of Target:
Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminus. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. The number of CAG repeats encoding the polyglutamine tract is usually 32-39, and expansion of the number of repeats increases the length of the polyglutamine string and is associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease. Two transcript variants encoding different isoforms have been found for this gene.
Swissprot Id:
P20226
Protein Accession #:
NP_001165556.1
Nucleotide Accession #:
NM_001172085.1
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express TBP.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express TBP.

Product Reviews

Protocol:
Tips Information:

Tell us what you think about this item!

Write A Review
    Please, wait...