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TBK1 Recombinant Protein (OPCD07299)

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Predicted Species Reactivity:
Human
Product Format:
Lyophilized
Host:
E.coli
Conjugation:
Unconjugated
Application:
SDS-PAGE, WB, ELISA, IP
Additional Information:
Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
:::
Residues: Trp9-Val310
Reconstitution and Storage:
Reconstitute in PBS or others.
Store at 2-8C for one month. Aliquot and store at -80C for 12 months. Avoid repeated freeze/thaw cycles.
Gene Symbol:
TBK1
Official Gene Full Name:
TANK binding kinase 1
Alias Symbols:
FLJ11330, NAK, NF-kappa-B-activating kinase, Serine/threonine-protein kinase TBK1, T2K
NCBI Gene Id:
29110
Protein Name:
Serine/threonine-protein kinase TBK1
Description of Target:
Serine/threonine kinase that plays an essential role in regulating inflammatory responses to foreign agents. Following activation of toll-like receptors by viral or bacterial components, associates with TRAF3 and TANK and phosphorylates interferon regulatory factors (IRFs) IRF3 and IRF7 as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRFs leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNA and IFNB. In order to establish such an antiviral state, TBK1 form several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including FADD, TRADD, MAVS, AZI2, TANK or TBKBP1/SINTBAD can be recruited to the TBK1-containing-complexes. Under particular conditions, functions as a NF-kappa-B effector by phosphorylating NF-kappa-B inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to the nucleus. Restricts bacterial proliferation by phosphorylating the autophagy receptor OPTN/Optineurin on 'Ser-177', thus enhancing LC3 binding affinity and antibacterial autophagy. Phosphorylates and activates AKT1. Seems to play a role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Attenuates retroviral budding by phosphorylating the endosomal sorting complex required for transport-I (ESCRT-I) subunit VPS37C. Phosphorylates Borna disease virus (BDV) P protein.1
Swissprot Id:
Q9UHD2
Protein Accession #:
NP_037386.1
Nucleotide Accession #:
NM_013254.3
Molecular Weight:
38 kDa
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express TBK1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express TBK1.
Formulation:
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Purity:
>90%
Source:
Prokaryotic Expressed Recombinant
Tag:
N-terminal His Tag
Datasheets/Manuals:
Printable datasheet for OPCD07299

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