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TARDBP Antibody (OAGA04563)

100 ul
$409.00
In Stock
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Predicted Species Reactivity:
Human, Mouse, Rat
Product Format:
Liquid
Clonality:
Polyclonal
Isotype:
IgG
Host:
Rabbit
Application:
ICC, IF, IHC-P, IP, WB, CHIP
Reconstitution and Storage:
Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
Gene Symbol:
TARDBP
Official Gene Full Name:
TAR DNA binding protein
NCBI Gene Id:
23435
Protein Name:
TAR DNA-binding protein 43
Swissprot Id:
Q13148
Protein Accession #:
NP_031401.1
Nucleotide Accession #:
NM_007375.3
Alias Symbols:
ALS10, TDP-43
Description of Target:
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
Purification:
Purified by antigen-affinity chromatography.
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express TARDBP.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express TARDBP.
Immunogen:
Recombinant protein encompassing a sequence within the center region of human TDP43. The exact sequence is proprietary.
Concentration:
1.01 mg/ml
Datasheets/Manuals:
Printable datasheet for OAGA04563
Preservative:
0.01% Thimerosal
Application Info:
Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IHC-P: 1:100-1:1000, IP: 1:100-1:1000 (target validated by Mass Spectrometry), WB: 1:500-1:3000, ChIP-seq. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Storage Buffer:
0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.

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