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TARDBP Antibody - N-terminal region (OAAB10063)

400ul
$390.00
In Stock
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Tested Species Reactivity:
Human, Mouse, Rat
Product Format:
Liquid. PBS with 0.09% (W/V) sodium azide.
Clonality:
Polyclonal
Isotype:
Ig
Host:
Rabbit
Application:
WB, IHC-P, IF, ELISA
:::
Function: RNA-binding protein that is involved in various steps of RNA biogenesis and processin. Preferentially binds, via its two RNA recognition motifs RRM1 and RRM2, to GU- repeats on RNA molecules predominantly localized within long introns and in the 3'UTR of mRNAs. In turn, regulates the splicing of many non-coding and protein-coding RNAs including proteins involved in neuronal survival, as well as mRNAs that encode proteins relevant for neurodegenerative diseases. Plays a role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts. Regulates also mRNA stability by recruiting CNOT7/CAF1 deadenylase on mRNA 3'UTR leading to poly(A) tail deadenylation and thus shortening. In response to oxidative insult, associates with stalled ribosomes localized to stress granules (SGs) and contributes to cell survival. Participates also in the normal skeletal muscle formation and regeneration, forming cytoplasmic myo-granules and binding mRNAs that encode sarcomeric proteins.
Cellular Location: Nucleus. Cytoplasm. Cytoplasm, Stress granule Note=Continuously travels in and out of the nucleus. Localizes to stress granules in response to oxidative stress.
Tissue Location: Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.
Reconstitution and Storage:
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
TARDBP
NCBI Gene Id:
23435
Protein Name:
TAR DNA-binding protein 43
Swissprot Id:
Q13148
Protein Accession #:
NP_031401.1
Alias Symbols:
TARDBP, TDP43, TAR DNA-binding protein 43
Replacement Item:
This antibody may replace item sc-100871 from Santa Cruz Biotechnology.
Description of Target:
HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20.
Molecular Weight:
45 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express TARDBP.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express TARDBP.
Immunogen:
This TARDBP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1-30 amino acids from the N-terminal region of human TARDBP.
Predicted Homology Based on Immunogen Sequence:
Chicken
Concentration:
0.4 mg/ml
Datasheets/Manuals:
Printable datasheet for OAAB10063
Intended Use:
TARDBP Antibody (N-term) is for research use only and not for use in diagnostic or therapeutic procedures.
Application Info:
WB: 1:2000
IF: 1:10~50
IHC-P: 1:10~50

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