TARDBP Antibody : FITC (OAPB00552-FITC)

Catalog No: OAPB00552-FITC

Size:0.1 mg

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: FITC: Fluorescein Isothiocyanate
• Application: ELISA, WB, ICC, IF
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen for anti-TDP43 antibody: antibody was raised against a 15 amino acid peptide from near the carboxy terminus of human TDP43.
• Purification: Affinity chromatography purified via peptide column
• Predicted Homology Based on Immunogen Sequence: Human; Mouse; Rat
• Concentration: 1 mg/ml
• Blocking Peptide: For anti-TARDBP (OAPB00552-FITC) antibody is Catalog # OEPB02674
• Specificity: At least two isoforms are known to exist for this protein; this TDP43 antibody will recognize both isoforms.
• Application Info: TDP43 antibody can be used for detection of TDP43 by Western blot at 0.5-2 ug/mL. Antibody can also be used for immunocytochemistry starting at 5 ug/mL. For immunofluorescence start at 20 ug/mL. Optimal dilutions for each application to be determined by the researcher.
• Reference: 1. Ou SH, Wu F, Garcia-Martinez LF, et al. Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs. J. Virol.1995; 69:3584-96.;
  2. Buratti E, Dork T, Zuccato E, et al. Nuclear factor TDP-43 and SR proteins promote in vitro and in vivo CFTR exon 9 skipping. EMBO J.2001; 20:1774-84.;
  3. Neumann M, Sampathu DM, Kwong LK, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science 2006; 314:42-3.;

Target Info

• Gene Symbol: TARDBP
• Gene Full Name: TAR DNA-binding protein 43
• Alias Symbols: ALS10, TDP-43
• NCBI Gene Id: 23435
• Protein Name: TAR DNA-binding protein 43
• Description of Target: (NT) TAR DNA binding protein
• Uniprot ID: Q13148
• Protein Accession #: NP_031401.1
• Nucleotide Accession #: NM_007375.3