TAOK1 Antibody (OAAF04256)

Catalog No: OAAF04256 (Formerly GWB-ASE991)

Size:100 ug

Western blot analysis of extracts from NIH-3T3 cells, using TAOK1 Antibody. The lane on the right is treated with the synthesized peptide.

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using TAOK1 Antibody. The picture on the right is treated with the synthesized peptide.

Product Info

• Predicted Species Reactivity: Human|Mouse|Rat
• Product Format: Liquid
• Clonality: Polyclonal
• Host: Rabbit
• Application: Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry|Immunohistochemistry-Paraffin|Western blot
• Reconstitution and Storage: -20°C
• Immunogen: The antiserum was produced against synthesized peptide derived from human TAOK1.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Specificity: TAOK1 antibody detects endogenous levels of total TAOK1 protein.
• Formulation: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
• Dilution: The optimal working dilution should be determined by the end user.
• Application Info: WB: 1:500~1:3000; IHC: 1:50~1:100; ELISA: 1:5000
• Reference: Yustein J.T., Oncogene 22:6129-6141(2003).
  Jenkins S.G., Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
  Matsuda A., Patent number WO2004058805, 15-JUL-2004.

Target Info

• Gene Symbol: TAOK1
• Gene Full Name: TAO kinase 1
• Alias Symbols: hKFC-B;hTAOK1;KFC-B;kinase from chicken homolog B;MAP3K16;MARK Kinase;MARKK;microtubule affinity regulating kinase kinase;prostate-derived STE20-like kinase 2;prostate-derived sterile 20-like kinase 2;PSK2;PSK-2;serine/threonine protein kinase TAO1 homolog;serine/threonine-protein kinase TAO1;STE20-like kinase PSK2;TAO1;thousand and one amino acid protein 1;thousand and one amino acid protein kinase 1.
• NCBI Gene Id: 57551
• Protein Name: Serine/threonine-protein kinase TAO1
• Description of Target: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability. Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade.
• Uniprot ID: Q7L7X3
• Protein Accession #: NP_065842.1
• Molecular Weight: 116 kDa