TAOK1 Antibody - middle region (OAAB16843)

Catalog No: OAAB16843

Size:400ul

Western blot analysis of anti-TAOK1 Pab (OAAB16843) in mouse brain tissue lysate (35ug/lane). TAOK1(arrow) was detected using the purified Pab (1:60 dilution).

Product Info

• Predicted Species Reactivity: Human
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Clonality: Polyclonal
• Isotype: Ig
• Host: Rabbit
• Application: WB
• Additional Information: Precautions: TAOK1 Antibody (Center) is for research use only and not for use in diagnostic or therapeutic procedures.
  Function: Serine/threonine-protein kinase involved in various processes such as p38/MAPK14 stress-activated MAPK cascade, DNA damage response and regulation of cytoskeleton stability Phosphorylates MAP2K3, MAP2K6 and MARK2. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade by mediating phosphorylation and subsequent activation of the upstream MAP2K3 and MAP2K6 kinases. Involved in G-protein coupled receptor signaling to p38/MAPK14. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of MAP2K3 and MAP2K6. Acts as a regulator of cytoskeleton stability by phosphorylating 'Thr-208' of MARK2, leading to activate MARK2 kinase activity and subsequent phosphorylation and detachment of MAPT/TAU from microtubules. Also acts as a regulator of apoptosis: regulates apoptotic morphological changes, including cell contraction, membrane blebbing and apoptotic bodies formation via activation of the MAPK8/JNK cascade
  Cellular Location: Cytoplasm.
  Tissue Location: Highly expressed in the testis, and to a lower extent also expressed in brain, placenta, colon and skeletal muscle
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This TAOK1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 620-650 amino acids from the Central region of human TAOK1.
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Application Info: WB: 1:1000

Target Info

• Gene Symbol: TAOK1
• Alias Symbols: PSK2, TAO1, KFC-B, MARKK, PSK-2, hKFC-B, hTAOK1, MAP3K16
• NCBI Gene Id: 57551
• Protein Name: Serine/threonine-protein kinase TAO1
• Description of Target: Purified Rabbit Polyclonal Antibody (Pab)
• Uniprot ID: Q7L7X3
• Protein Accession #: NP_065842.1
• Molecular Weight: 116070 Da