TANK Recombinant Protein (OPCD07280)

Catalog No: OPCD07280

TANK Recombinant Protein (OPCD07280) using SDS-PAGE

TANK Recombinant Protein (OPCD07280) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Homo sapiens|Human
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Leu131-Ile369
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: TANK
• Gene Full Name: TRAF family member associated NFKB activator
• Alias Symbols: ITRAF;I-TRAF;TRAF family member-associated NF-kappa-B activator;TRAF2;TRAF-interacting protein.
• NCBI Gene Id: 10010
• Protein Name: TRAF family member-associated NF-kappa-B activator
• Description of Target: Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. Negatively regulates NF-kappaB signaling and cell survival upon DNA damage (PubMed:25861989). Plays a role as an adapter to assemble ZC3H12A, USP10 in a deubiquitination complex which plays a negative feedback response to attenuate NF-kappaB activation through the deubiquitination of IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Promotes UBP10-induced deubiquitination of TRAF6 in response to DNA damage (PubMed:25861989). May control negatively TRAF2-mediated NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2.
• Uniprot ID: Q92844
• Protein Accession #: NP_001186064.1
• Nucleotide Accession #: NM_001199135.1
• Protein Size (# AA): Leu131~Ile369
• Molecular Weight: 33kDa