Size:100 ul
Special Price $229.00 Regular Price $289.00
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SKU
ARP74274_P050
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Conjugation Options

ARP74274_P050-FITC Conjugated

ARP74274_P050-HRP Conjugated

ARP74274_P050-Biotin Conjugated

TAB2 Antibody - middle region (ARP74274_P050)

Catalog#: ARP74274_P050
Domestic: within 1-2 days delivery | International: 1-2 days
More Information
Tested Species ReactivityHuman
Predicted Species ReactivityHuman
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement ItemThis antibody may replace item sc-398188 from Santa Cruz Biotechnology.
ImmunogenThe immunogen is a synthetic peptide directed towards the middle region of Human TAB2
PurificationAffinity Purified
Peptide SequenceSynthetic peptide located within the following region: SGSSQSSAHSQYNIQNISTGPRKNQIEIKLEPPQRNNSSKLRSSGPRTSS
ConcentrationBatch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking PeptideFor anti-TAB2 (ARP74274_P050) antibody is Catalog # AAP74274
Datasheets/ManualsPrintable datasheet for anti-TAB2 (ARP74274_P050) antibody
Gene SymbolTAB2
Alias SymbolsTAB2, KIAA0733, MAP3K7IP2,
NCBI Gene Id23118
Description of TargetThe protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants.
Swissprot IdQ9NYJ8-2
Protein Size (# AA)536
Molecular Weight58kDa
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express TAB2.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express TAB2.
Protein InteractionsUBC; PIAS3; UBE2I; TRAF6; SUMO2; IRAK1; MAP3K7; TRIM38; SIK1; SIK3; TRIM22; NPM1; CST9L; SLC19A3; env; TAB1; NUMBL; IKBKG; FOSL1; ZBTB16; YWHAZ; VIM; TGM2; PPP2CB; IKBKB; GTF2I; FN1; HSP90AA1; BST2; MALT1; WDR34; APP; ESR1; MAP3K8; AR; TRIM5; TBL1XR1; MBD
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