SWAP70 Antibody - N-terminal region : FITC (ARP46214_T100-FITC)

Catalog No: ARP46214_T100-FITC

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: FITC: Fluorescein Isothiocyanate
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SWAP70
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%
• Peptide Sequence: Synthetic peptide located within the following region: ALEEHFRDDDEGPVSNQGYMPYLNRFILEKVQDNFDKIEFNRMCWTLCVK
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-SWAP70 (ARP46214_T100-FITC) antibody is Catalog # AAP46214 (Previous Catalog # AAPP27049)
• Reference: Liu,J., (2007) J. Histochem. Cytochem. 55 (7), 701-708

Target Info

• Gene Symbol: SWAP70
• Gene Full Name: SWAP switching B-cell complex 70kDa subunit
• Alias Symbols: HSPC321, SWAP-70
• NCBI Gene Id: 23075
• Protein Name: Switch-associated protein 70
• Description of Target: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. SWAP70 also mediates signaling of membrane ruffling. It regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.
• Uniprot ID: Q9UH65
• Protein Accession #: NP_055870
• Nucleotide Accession #: NM_015055
• Protein Size (# AA): 585
• Molecular Weight: 69kDa
• Protein Interactions: ZBTB5; RAPGEF4; UBC; CORO1B; ASUN; OTUD6B; JMJD6; GANAB; PACSIN2; FAF1; PAICS; FARSB; ZRANB2; RANBP3; CUL1; SUPT5H; SET; PPP2R5C; PLOD2; OSBP; GART; XRCC6; CRMP1; ATP6V1B2; C18orf8; CELSR3; IGHG1; PARP1; NPM1; NCL;