Search Antibody, Protein, and ELISA Kit Solutions

SWAP70 Antibody (Ascites) (OAAB06992)

0.1 ml
$329.00
In Stock
Request Bulk Order Quote

Predicted Species Reactivity:
Human
Product Format:
Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.
Clonality:
Monoclonal
Clone:
434CT16.5.5
Isotype:
IgG1
Host:
Mouse
Application:
WB
Additional Information:
Precautions: SWAP70 Antibody(Ascites) is for research use only and not for use in diagnostic or therapeutic procedures.
:::
Function: Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion (By similarity)
:::
Cellular Location: Cytoplasm. Cell membrane. Nucleus. Cell projection, lamellipodium. Note=In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamell
Tissue Location: Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus- associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760)
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item:
This antibody may replace item sc-10882 from Santa Cruz Biotechnology.
Immunogen:
Purified His-tagged SWAP70 protein(Fragment) was used to produced this monoclonal antibody.
Predicted Homology Based on Immunogen Sequence:
Human
Datasheets/Manuals:
Printable datasheet for OAAB06992
Sample Type Confirmation:

There is BioGPS gene expression data showing that SWAP70 is expressed in MDA-MB231

Application Info:
WB: 1:1000~8000
Gene Symbol:
SWAP70
Alias Symbols:
SWAP70, KIAA0640, Switch-associated protein 70
NCBI Gene Id:
23075
Protein Name:
Switch-associated protein 70
Description of Target:
Mouse Monoclonal Antibody (Mab)
Swissprot Id:
Q9UH65
Protein Accession #:
NP_055870.2
Molecular Weight:
68998 Da
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express SWAP70.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express SWAP70.

Product Reviews

Tell us what you think about this item!

Write A Review
    Please, wait...