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SUV4-20H1 Antibody - C-terminal region (OAAB08316)

400ul
$390.00
In Stock
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Gene Symbol:
SUV420H1
NCBI Gene Id:
51111
Protein Name:
Histone-lysine N-methyltransferase SUV420H1
Swissprot Id:
Q4FZB7
Protein Accession #:
NP_057112.3
Alias Symbols:
SUV420H1, KMT5B, Histone-lysine N-methyltransferase SUV420H1, Lysine N-methyltransferase 5B, Suppressor of variegation 4-20 homolog 1
Replacement Item:
This antibody may replace item sc-134048 from Santa Cruz Biotechnology.
Description of Target:
Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Molecular Weight:
99187 Da
Host:
Rabbit
Clonality:
Polyclonal
Application:
WB, FC
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express SUV420H1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express SUV420H1.
Immunogen:
This SUV4-20H1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 759-789 amino acids from the C-terminal region of human SUV4-20H1.
Predicted Homology Based on Immunogen Sequence:
Human
Product Format:
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Reconstitution and Storage:
Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Approximately 0.5mg/ml. Actual concentration varies with each lot.
Datasheets/Manuals:
Printable datasheet for OAAB08316
Isotype:
Ig
Application Info:
WB: 1:500
WB: 1:1000
FC: 1:10~50
Additional Information:
Precautions: SUV4-20H1 Antibody (C-term) is for research use only and not for use in diagnostic or therapeutic procedures.
:::
Function: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4. H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. SUV420H1 is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity)
:::
Cellular Location: Nucleus. Chromosome (By similarity). Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity)

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