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SUR1 Antibody (OASE00257)

100ug
$379.00
In Stock
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Conjugation Options

OASE00257-FITC Conjugated

OASE00257-HRP Conjugated

OASE00257-Biotin Conjugated

Predicted Species Reactivity:
Mouse, Hamster, Rat
Clonality:
Monoclonal
Clone:
S289-16
Isotype:
IgG1
Host:
Mouse
Application:
WB, IHC, ICC
Additional Information:
Background Info: Detects ~160kDa. Does not cross-react with SUR2B
:::
Scientific Background: Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2) (1). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell (2).
:::
Certificate of Analysis: 1ug/mL was sufficient for detection of SUR1 in 20ug of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Reconstitution and Storage:
Store at -20C. Shipping in Blue Ice or 4C.
Replacement Item:
This antibody may replace item sc-25683 from Santa Cruz Biotechnology.
Immunogen:
Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1
Purification:
Protein G Purified
Concentration:
1mg/mL
Datasheets/Manuals:
Printable datasheet for OASE00257
Dilution:
1ug/mL (WB), 0.1-1ug/mL (IHC/ICC), 1-10ug/mL (IF)
Storage Buffer:
PBS pH7.4, 50% glycerol
Target Reference:
1.     Campbell J.D., Sansom M.S., Ashcroft F.M. (2003) EMBO Resp. 4(11): 1038-1042. 2.     Nichols C.G. (2006) Nature. 440 (7083): 470-476.
Gene Symbol:
Abcc8
Official Gene Full Name:
ATP-binding cassette, subfamily C (CFTR/MRP), member 8
NCBI Gene Id:
25559
Swissprot Id:
Q09429
Protein Accession #:
NP_037171.2
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express Abcc8.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express Abcc8.

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