Size:100ug
$379.00
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SKU
OASE00257
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Conjugation Options

OASE00257-FITC Conjugated

OASE00257-HRP Conjugated

OASE00257-Biotin Conjugated

SUR1 Antibody (OASE00257)

Catalog#: OASE00257
Domestic: within 3-5 days delivery | International: 3-5 days
More Information
Predicted Species Reactivity Mouse, Hamster, Rat
Clonality Monoclonal
Clone S289-16
Isotype IgG1
Host Mouse
Application WB, IHC, ICC
Additional Information Background Info: Detects ~160kDa. Does not cross-react with SUR2B
:: Scientific Background: Sulfonylurea receptors (SUR) are membrane proteins which are the molecular targets of the sulfonylurea class of anti-diabetic drugs whose mechanism of action is to promote insulin release from pancreatic beta cells. More specifically, SUR proteins are subunits of the inward-rectifier potassium ion channels Kir6.x (6.1 and 6.2) (1). The association of four Kir6.x and four SUR subunits form an ion conducting channel commonly referred to as the KATP channel. The primary function of the sulfonylurea receptor is to sense intracellular levels of the nucleotides ATP and ADP and in response facilitate the open or closing its associated Kir6.x potassium channel. Hence the KATP channel monitors the energy balance within the cell (2).
:: Certificate of Analysis: 1ug/mL was sufficient for detection of SUR1 in 20ug of mouse brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Reconstitution and Storage Store at -20C. Shipping in Blue Ice or 4C.
Replacement Item This antibody may replace item sc-25683 from Santa Cruz Biotechnology.
Immunogen Fusion protein amino acids 1548-1582 (cytoplasmic C-terminus) of rat SUR1
Purification Protein G Purified
Concentration 1mg/mL
Datasheets/Manuals Printable datasheet for OASE00257
Dilution 1ug/mL (WB), 0.1-1ug/mL (IHC/ICC), 1-10ug/mL (IF)
Storage Buffer PBS pH7.4, 50% glycerol
Target Reference 1.     Campbell J.D., Sansom M.S., Ashcroft F.M. (2003) EMBO Resp. 4(11): 1038-1042. 2.     Nichols C.G. (2006) Nature. 440 (7083): 470-476.
Gene Symbol Abcc8
Official Gene Full Name ATP-binding cassette, subfamily C (CFTR/MRP), member 8
NCBI Gene Id 25559
Swissprot Id Q09429
Protein Accession # NP_037171.2
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express Abcc8.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express Abcc8.
  1. What is the species homology for "SUR1 Antibody (OASE00257)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Mouse, Hamster, Rat".

  2. How long will it take to receive "SUR1 Antibody (OASE00257)"?

    This item is available "Domestic: within 3-5 days delivery | International: 3-5 days".

  3. What buffer format is "SUR1 Antibody (OASE00257)" provided in?

    This item is provided in "".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "SUR1 Antibody (OASE00257)"?

    This target may also be called "" in publications.

  5. What is the shipping cost for "SUR1 Antibody (OASE00257)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "SUR1 Antibody (OASE00257)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "SUR1 Antibody (OASE00257)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "SUR1 Antibody (OASE00257)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "ABCC8"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ABCC8"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ABCC8"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ABCC8"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ABCC8"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ABCC8"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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