STX1A Antibody (OAED00249)

Catalog No: OAED00249

Size:100 ug

Immunohistochemistry analysis of human brain, cortex tissue stained with Syntaxin 1A, pAb at 10 ug/ml.

Product Info

• Predicted Species Reactivity: Mouse, Rat, Bovine
• Clonality: Polyclonal
• Host: Rabbit
• Application: IHC, IP, WB
• Reconstitution and Storage: Long Term Storage : -20C
  
• Immunogen: Synthetic peptide corresponding to a portion of rat Syntaxin 1A.
• Specificity: Recognizes mouse, rat and bovine Syntaxin 1A. Detects a band of ~35-36kDa by Western blot.
• Formulation: Liquid. In PBS, pH 7.2, containing 50% glycerol and 0.09% sodium azide.
• Purity: Protein A affinity purified.
  
• Application Info: Immunohistochemistry (paraffin sections)
  Immunoprecipitation
  Western Blot (1μg/ml, colorimetric)
  Optimal conditions must be determined individually for each application.
• Reference: Glucose-stimulated insulin secretion is coupled to the interaction of actin with the t-SNARE (target membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor protein) complex: J.E. Pessin, et al. ; Mol. Endocrinol. 17, 732 (2003), Application(s): WB using rat samples, Abstract;
  Identification of SNARE and cell trafficking regulatory proteins in the salivary glands of the lone star tick, Amblyomma americanum (L.): J.R. Sauer, et al. ; Insect Biochem. Mol. Biol. 32, 1711 (2002), Application(s): WB using insect samples, Abstract;
  Synaptotagmin I is a molecular target for lead: J. Pevsner, et al. ; J. Neurochem. 76, 1724 (2001), Application(s): IP using rat samples, Abstract;
  G protein modulation of N-type calcium channels is facilitated by physical interactions between syntaxin 1A and G beta gamma: G.W. Zamponi, et al. ; J. Biol. Chem. 275, 6388 (2000), Application(s): WB using rat samples, Abstract;
  

Target Info

• Gene Symbol: STX1A
• Gene Full Name: Syntaxin-1A
• Alias Symbols: STX1, HPC-1, P35-1, SYN1A
• NCBI Gene Id: 6804
• Protein Name: Syntaxin-1A
• Description of Target: Syntaxins are type II integral membrane proteins localized to membranes that regulate vesicle transport, protein maturation, and exocytosis. Syntaxin 1A resides in the nerve terminals of sensory neurons and nerve fibers reaching small blood vessels. Syntaxin 2 localizes to the apical plasma membrane and regulates epithelial-mesenchymal interactions. Syntaxin 6 is primarily localized to the trans-Golgi network, and partially co-localizes with AP-1 on clathrin-coated membranes. Syntaxin 13 is ubiquitously expressed and localizes to the tubular early and recycling endosomes, as well as endosomal vacuoles.
• Uniprot ID: Q16623
• Protein Accession #: NP_001159375.1; NP_004594.1
• Nucleotide Accession #: NM_001165903.1; NM_004603.3