STX1A Antibody - N-terminal region : FITC (AVARP13091_P050-FITC)

Catalog No: AVARP13091_P050-FITC

Size:100ul

Product Info

• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer.
• Clonality: Polyclonal
• Host: Rabbit
• Conjugation: FITC: Fluorescein Isothiocyanate
• Application: WB
• Reconstitution and Storage: All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil). Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human STX1A
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Human: 100%; Mouse: 100%; Rat: 100%
• Peptide Sequence: Synthetic peptide located within the following region: KDRTQELRTAKDSDDDDDVAVTVDRDRFMDEFFEQVEEIRGFIDKIAENV
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-STX1A (AVARP13091_P050-FITC) antibody is Catalog # AAP30760 (Previous Catalog # AAPP01421)
• Reference: Kawashima,K., (er) Am. J. Med. Genet. B Neuropsychiatr. Genet. (2008) In press

Target Info

• Gene Symbol: STX1A
• Gene Full Name: Syntaxin 1A (brain)
• Alias Symbols: STX1, HPC-1, P35-1, SYN1A
• NCBI Gene Id: 6804
• Protein Name: Syntaxin-1A
• Description of Target: Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor which produces explosive exocytosis. Synaptic vesicles store neurotransmitters that are released during calcium-regulated exocytosis. The specificity of neurotransmitter release requires the localization of both synaptic vesicles and calcium channels to the presynaptic active zone. Syntaxins function in this vesicle fusion process. Syntaxins also serve as a substrate for botulinum neurotoxin type C, a metalloprotease that blocks exocytosis and has high affinity for a molecular complex that includes the alpha-latrotoxin receptor (MIM 600565) which produces explosive exocytosis (Zhang et al., 1995 [PubMed 7622072]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1253 BC064644.1 1-1253 1254-2117 BC000444.2 1209-2072
• Uniprot ID: Q16623
• Protein Accession #: NP_004594
• Nucleotide Accession #: NM_004603
• Protein Size (# AA): 288
• Molecular Weight: 33kDa
• Protein Interactions: STXBP1; SUMO1P1; TXLNA; TXLNB; NAPB; VAMP5; SNAP29; VAPB; SNAP23; STX1A; PSMA3; KCNB1; Htt; SNAP25; SLC6A3; SLC6A2; PPP1CA; pnut; Sep1; SNPH; TRDMT1; CCSER2; VPS11; SYT7; VPS18; RIMS1; CPLX1; SLC6A5; STXBP5; SYTL4; STXBP6; UNC13B; STX8; RAB27A; NAPA; VAMP